Survival outcome of tyrosine kinase inhibitors beyond progression in association to radiotherapy in oligoprogressive EGFR-mutant non-small-cell lung cancer

The association of tyrosine kinase inhibitors (TKIs) and local radiotherapy in -mutated non-small-cell lung cancer patients experiencing disease progression under TKIs could be a valid an option. We included 131 patients experiencing disease progression during first-line TKI. In group A, patients re...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2019-11, Vol.15 (33), p.3775-3782
Main Authors: Rossi, Sabrina, Finocchiaro, Giovanna, Noia, Vincenzo Di, Bonomi, Maria, Cerchiaro, Eleonora, Rose, Fiorenza De, Franceschini, Davide, Navarria, Pierina, Ceresoli, Giovanni Luca, Beretta, Giordano Domenico, D'Argento, Ettore, Scorsetti, Marta, Santoro, Armando, Toschi, Luca
Format: Article
Language:English
Subjects:
Adult
afatinib
Afatinib - pharmacology
Afatinib - therapeutic use
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - therapy
Chemoradiotherapy - methods
Chemotherapy
Disease Progression
DNA Mutational Analysis
Drug Resistance, Neoplasm - genetics
Drug Resistance, Neoplasm - radiation effects
EGFR mutations
ErbB Receptors - antagonists & inhibitors
ErbB Receptors - genetics
Female
gefitinib
Gefitinib - pharmacology
Gefitinib - therapeutic use
Humans
Kinases
Lung - diagnostic imaging
Lung - drug effects
Lung - pathology
Lung - radiation effects
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Lung Neoplasms - therapy
Lymphatic system
Male
Metastasis
Middle Aged
Mutation
NSCLC
oligoprogression
Patients
Progression-Free Survival
Protein Kinase Inhibitors - pharmacology
Protein Kinase Inhibitors - therapeutic use
Radiation therapy
Radiofrequency Ablation
radiotherapy
Retrospective Studies
Targeted cancer therapy
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Summary:The association of tyrosine kinase inhibitors (TKIs) and local radiotherapy in -mutated non-small-cell lung cancer patients experiencing disease progression under TKIs could be a valid an option. We included 131 patients experiencing disease progression during first-line TKI. In group A, patients received TKI beyond progression and site(s) of progression were irradiated; in group B, patients remained on TKI alone beyond progression; and group C stopped TKI at first disease progression. Median overall survival resulted longer in group A versus B and C (p 
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2019-0349