Bisphenol A triggers the malignancy of acute myeloid leukemia cells via regulation of IL‐4 and IL‐6

Acute myeloid leukemia (AML) is a cancer of hematopoietic stem cells with a rapid progression. The progression of AML can be regulated by estrogenic signals. Our present data showed that an industrial endocrine‐disrupting chemical, bisphenol A (BPA), can promote the proliferation of AML cells and de...

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Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2020-01, Vol.34 (1), p.e22412-n/a
Main Authors: Zhang, Suwei, Li, Jiazhen, Fan, Jingru, Wu, Xianheng
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
AML
Antibodies
Antibodies, Neutralizing - immunology
Benzhydryl Compounds - pharmacology
Bisphenol A
BPA
Cell proliferation
Cell Proliferation - drug effects
Cytarabine
Cytokines
Daunorubicin
Disruption
Estrogens, Non-Steroidal - pharmacology
Hematopoietic stem cells
HL-60 Cells
Humans
IL‐4
IL‐6
Interleukin-4 - immunology
Interleukin-4 - metabolism
Interleukin-6 - immunology
Interleukin-6 - metabolism
Interleukins
Leukemia
Leukemia, Myeloid, Acute - metabolism
Leukemia, Myeloid, Acute - pathology
Malignancy
Myeloid leukemia
Neutralization
NF-AT1 protein
NFATC Transcription Factors - metabolism
Organic chemistry
Phenols
Phenols - pharmacology
proliferation
Stem cells
Transcription
U937 Cells
Xenoestrogens
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Summary:Acute myeloid leukemia (AML) is a cancer of hematopoietic stem cells with a rapid progression. The progression of AML can be regulated by estrogenic signals. Our present data showed that an industrial endocrine‐disrupting chemical, bisphenol A (BPA), can promote the proliferation of AML cells and decrease their sensitivity to daunorubicin and cytarabine treatment. Among the tested cytokines, BPA treatment can decrease the expression of interleukin‐4 (IL‐4) while increasing the expression of IL‐6. Overexpression of IL‐4 or neutralization antibody of IL‐6 (anti‐IL‐6) can attenuate BPA‐induced proliferation of AML cells and reverse BPA‐suppressed chemosensitivity. Furthermore, activation of nuclear factor kappa B is essential for BPA‐induced upregulation of IL‐6 in AML cells. As to IL‐4, BPA can increase the expression of NFAT1 to inhibit its transcription. Collectively, our data showed that BPA can trigger the malignancy of AML cells via regulation of IL‐4 and IL‐6.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22412