Transformation of Grade II to Grade III Rhabdoid–Papillary Meningioma: Is Stereotactic Radiosurgery the Culprit? A Case Report and Literature Review

In the management of meningiomas, single-fraction stereotactic radiosurgery (SRS) is an established alternative treatment to surgical resection. However, its effects on tumorigenesis and malignant transformation are still uncertain. We have described a grade II parafalcine meningioma that was initia...

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Bibliographic Details
Published in:World neurosurgery 2020-02, Vol.134, p.337-342
Main Authors: Christodoulides, Ioannis, Lavrador, José Pedro, Bodi, Istvan, Laxton, Ross, Gullan, Richard, Bhangoo, Ranjeev, Vergani, Francesco, Ashkan, Keyoumars
Format: Article
Language:English
Subjects:
Aged
Cell Transformation, Neoplastic - radiation effects
Female
Humans
Meningeal Neoplasms - pathology
Meningeal Neoplasms - radiotherapy
Meningioma
Meningioma - pathology
Meningioma - radiotherapy
Neoplasm Recurrence, Local - pathology
Radiosurgery - adverse effects
Rhabdoid papillary lesion
Stereotactic radiosurgery
Surgery
TERT
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Summary:In the management of meningiomas, single-fraction stereotactic radiosurgery (SRS) is an established alternative treatment to surgical resection. However, its effects on tumorigenesis and malignant transformation are still uncertain. We have described a grade II parafalcine meningioma that was initially surgically resected (Simpson 2 clearance) and then managed with a single dose of SRS on recurrence. The tumor recurred again 7 years later, with histological features of a grade III rhabdoid–papillary lesion, with local brain invasion. To the best of our knowledge, this is the first report to describe malignant transformation of a grade II to grade III meningioma after SRS to date.
ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2019.11.019