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Screening for diabetic retinopathy in diabetic patients with a mydriasis-free, full-field flicker electroretinogram recording device
Purpose To investigate the accuracy of the RETeval full-field flicker ERG in the screening of diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) and to determine a suitable range of DR diagnostic reference for patients with type 2 diabetes mellitus (T2DM). Methods This was...
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| Published in: | Documenta ophthalmologica 2020-06, Vol.140 (3), p.211-220 |
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| cites | cdi_FETCH-LOGICAL-c375t-e967807d68014abac3a4d6775c9ab49460fde1bd553601b17a67c73d188e3ae53 |
| container_end_page | 220 |
| container_issue | 3 |
| container_start_page | 211 |
| container_title | Documenta ophthalmologica |
| container_volume | 140 |
| creator | Zeng, Yunkao Cao, Dan Yang, Dawei Zhuang, Xuenan Yu, Honghua Hu, Yunyan Zhang, Yan Yang, Cheng He, Miao Zhang, Liang |
| description | Purpose
To investigate the accuracy of the RETeval full-field flicker ERG in the screening of diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) and to determine a suitable range of DR diagnostic reference for patients with type 2 diabetes mellitus (T2DM).
Methods
This was a cross-sectional study involving 172 subjects with T2DM, including 71 subjects without clinically detectable DR (NDR), 25 subjects with mild non-proliferative diabetic retinopathy (NPDR), 24 subjects with moderate NPDR, 27 subjects with severe NPDR and 25 subjects with proliferative diabetic retinopathy (PDR). All the subjects underwent a full-field flicker ERG using the RETeval device (DR assessment protocol), which is a mydriasis-free, full-field electroretinogram (ERG) recording system. The performance of the DR assessment protocol in detecting the DR (including mild NPDR, moderate NPDR, severe NPDR and PDR) and VTDR was analyzed with the receiver operating characteristic (ROC) curve.
Results
For the detection of DR (mild NPDR, moderate NPDR, severe NPDR, PDR), the area under the ROC curve was 0.867 (
p
|
| doi_str_mv | 10.1007/s10633-019-09734-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2314253946</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2314253946</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-e967807d68014abac3a4d6775c9ab49460fde1bd553601b17a67c73d188e3ae53</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhq0KVLbb_gEOlSUuHGo6_oidHKsV_ZCQOEDPkWNPFkM-tnZCtff-cAyhReqBy4w0fuYZSy8hxxzOOID5nDhoKRnwikFlpGLiDVnxwkgmtBAHZAXABVOq1EfkXUq3ABnj5VtyJLkRUJWwIn-uXEQcwrCl7RipD7bBKTgacx3GnZ1u9jQML_M8CThMif4O0w21tN_7GGwKibXZ84m2c9exNmDnadsFd4eRYoduiuNi3EbbZ7kbo3-86fE-OHxPDlvbJfzw3Nfk59fz6813dnH57cfmywVz0hQTw0qbEozXJXBlG-ukVV4bU7jKNqpSGlqPvPFFITXwhhurjTPS87JEabGQa3K6eHdx_DVjmuo-JIddZwcc51QLyZUoZDZl9OQ_9Hac45B_l6mq0hJUCZkSC-XimFLEtt7F0Nu4rznUjxnVS0Z1zqh-yihvr8nHZ_Xc9Oj_rfwNJQNyAVJ-GrYYX26_on0AotieQA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2399630480</pqid></control><display><type>article</type><title>Screening for diabetic retinopathy in diabetic patients with a mydriasis-free, full-field flicker electroretinogram recording device</title><source>Springer Link</source><creator>Zeng, Yunkao ; Cao, Dan ; Yang, Dawei ; Zhuang, Xuenan ; Yu, Honghua ; Hu, Yunyan ; Zhang, Yan ; Yang, Cheng ; He, Miao ; Zhang, Liang</creator><creatorcontrib>Zeng, Yunkao ; Cao, Dan ; Yang, Dawei ; Zhuang, Xuenan ; Yu, Honghua ; Hu, Yunyan ; Zhang, Yan ; Yang, Cheng ; He, Miao ; Zhang, Liang</creatorcontrib><description>Purpose
To investigate the accuracy of the RETeval full-field flicker ERG in the screening of diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) and to determine a suitable range of DR diagnostic reference for patients with type 2 diabetes mellitus (T2DM).
Methods
This was a cross-sectional study involving 172 subjects with T2DM, including 71 subjects without clinically detectable DR (NDR), 25 subjects with mild non-proliferative diabetic retinopathy (NPDR), 24 subjects with moderate NPDR, 27 subjects with severe NPDR and 25 subjects with proliferative diabetic retinopathy (PDR). All the subjects underwent a full-field flicker ERG using the RETeval device (DR assessment protocol), which is a mydriasis-free, full-field electroretinogram (ERG) recording system. The performance of the DR assessment protocol in detecting the DR (including mild NPDR, moderate NPDR, severe NPDR and PDR) and VTDR was analyzed with the receiver operating characteristic (ROC) curve.
Results
For the detection of DR (mild NPDR, moderate NPDR, severe NPDR, PDR), the area under the ROC curve was 0.867 (
p
< 0.001, 95% CI 0.814–0.920), and the best cutoff value for DR was determined to be 20.75, with a sensitivity of 80.2% and specificity of 81.7%. Meanwhile, for the detection of VTDR, the area under the ROC curve was 0.965 (
p
< 0.001, 95% CI 0.941–0.989), and the best cutoff value was set to 23.05, with a sensitivity of 94.6% and a specificity of 88.8%.
Conclusion
The DR assessment protocol in RETeval device was effective in screening for DR (mild NPDR, moderate NPDR, severe NPDR, PDR) and VTDR in patients with diabetes. It could be helpful in referring and managing patients with T2DM in primary healthcare setting. However, caution should be taken that optimal cutoff value of DR assessment protocol may vary in different ethnic populations.</description><identifier>ISSN: 0012-4486</identifier><identifier>EISSN: 1573-2622</identifier><identifier>DOI: 10.1007/s10633-019-09734-2</identifier><identifier>PMID: 31720980</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetic retinopathy ; Electroretinograms ; Medicine ; Medicine & Public Health ; Ophthalmology ; Original Research Article ; Retina ; Retinopathy</subject><ispartof>Documenta ophthalmologica, 2020-06, Vol.140 (3), p.211-220</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e967807d68014abac3a4d6775c9ab49460fde1bd553601b17a67c73d188e3ae53</citedby><cites>FETCH-LOGICAL-c375t-e967807d68014abac3a4d6775c9ab49460fde1bd553601b17a67c73d188e3ae53</cites><orcidid>0000-0002-0454-8001</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31720980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Yunkao</creatorcontrib><creatorcontrib>Cao, Dan</creatorcontrib><creatorcontrib>Yang, Dawei</creatorcontrib><creatorcontrib>Zhuang, Xuenan</creatorcontrib><creatorcontrib>Yu, Honghua</creatorcontrib><creatorcontrib>Hu, Yunyan</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Yang, Cheng</creatorcontrib><creatorcontrib>He, Miao</creatorcontrib><creatorcontrib>Zhang, Liang</creatorcontrib><title>Screening for diabetic retinopathy in diabetic patients with a mydriasis-free, full-field flicker electroretinogram recording device</title><title>Documenta ophthalmologica</title><addtitle>Doc Ophthalmol</addtitle><addtitle>Doc Ophthalmol</addtitle><description>Purpose
To investigate the accuracy of the RETeval full-field flicker ERG in the screening of diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) and to determine a suitable range of DR diagnostic reference for patients with type 2 diabetes mellitus (T2DM).
Methods
This was a cross-sectional study involving 172 subjects with T2DM, including 71 subjects without clinically detectable DR (NDR), 25 subjects with mild non-proliferative diabetic retinopathy (NPDR), 24 subjects with moderate NPDR, 27 subjects with severe NPDR and 25 subjects with proliferative diabetic retinopathy (PDR). All the subjects underwent a full-field flicker ERG using the RETeval device (DR assessment protocol), which is a mydriasis-free, full-field electroretinogram (ERG) recording system. The performance of the DR assessment protocol in detecting the DR (including mild NPDR, moderate NPDR, severe NPDR and PDR) and VTDR was analyzed with the receiver operating characteristic (ROC) curve.
Results
For the detection of DR (mild NPDR, moderate NPDR, severe NPDR, PDR), the area under the ROC curve was 0.867 (
p
< 0.001, 95% CI 0.814–0.920), and the best cutoff value for DR was determined to be 20.75, with a sensitivity of 80.2% and specificity of 81.7%. Meanwhile, for the detection of VTDR, the area under the ROC curve was 0.965 (
p
< 0.001, 95% CI 0.941–0.989), and the best cutoff value was set to 23.05, with a sensitivity of 94.6% and a specificity of 88.8%.
Conclusion
The DR assessment protocol in RETeval device was effective in screening for DR (mild NPDR, moderate NPDR, severe NPDR, PDR) and VTDR in patients with diabetes. It could be helpful in referring and managing patients with T2DM in primary healthcare setting. However, caution should be taken that optimal cutoff value of DR assessment protocol may vary in different ethnic populations.</description><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetic retinopathy</subject><subject>Electroretinograms</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Research Article</subject><subject>Retina</subject><subject>Retinopathy</subject><issn>0012-4486</issn><issn>1573-2622</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU1P3DAQhq0KVLbb_gEOlSUuHGo6_oidHKsV_ZCQOEDPkWNPFkM-tnZCtff-cAyhReqBy4w0fuYZSy8hxxzOOID5nDhoKRnwikFlpGLiDVnxwkgmtBAHZAXABVOq1EfkXUq3ABnj5VtyJLkRUJWwIn-uXEQcwrCl7RipD7bBKTgacx3GnZ1u9jQML_M8CThMif4O0w21tN_7GGwKibXZ84m2c9exNmDnadsFd4eRYoduiuNi3EbbZ7kbo3-86fE-OHxPDlvbJfzw3Nfk59fz6813dnH57cfmywVz0hQTw0qbEozXJXBlG-ukVV4bU7jKNqpSGlqPvPFFITXwhhurjTPS87JEabGQa3K6eHdx_DVjmuo-JIddZwcc51QLyZUoZDZl9OQ_9Hac45B_l6mq0hJUCZkSC-XimFLEtt7F0Nu4rznUjxnVS0Z1zqh-yihvr8nHZ_Xc9Oj_rfwNJQNyAVJ-GrYYX26_on0AotieQA</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Zeng, Yunkao</creator><creator>Cao, Dan</creator><creator>Yang, Dawei</creator><creator>Zhuang, Xuenan</creator><creator>Yu, Honghua</creator><creator>Hu, Yunyan</creator><creator>Zhang, Yan</creator><creator>Yang, Cheng</creator><creator>He, Miao</creator><creator>Zhang, Liang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0454-8001</orcidid></search><sort><creationdate>20200601</creationdate><title>Screening for diabetic retinopathy in diabetic patients with a mydriasis-free, full-field flicker electroretinogram recording device</title><author>Zeng, Yunkao ; Cao, Dan ; Yang, Dawei ; Zhuang, Xuenan ; Yu, Honghua ; Hu, Yunyan ; Zhang, Yan ; Yang, Cheng ; He, Miao ; Zhang, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e967807d68014abac3a4d6775c9ab49460fde1bd553601b17a67c73d188e3ae53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetic retinopathy</topic><topic>Electroretinograms</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Research Article</topic><topic>Retina</topic><topic>Retinopathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Yunkao</creatorcontrib><creatorcontrib>Cao, Dan</creatorcontrib><creatorcontrib>Yang, Dawei</creatorcontrib><creatorcontrib>Zhuang, Xuenan</creatorcontrib><creatorcontrib>Yu, Honghua</creatorcontrib><creatorcontrib>Hu, Yunyan</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Yang, Cheng</creatorcontrib><creatorcontrib>He, Miao</creatorcontrib><creatorcontrib>Zhang, Liang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Documenta ophthalmologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Yunkao</au><au>Cao, Dan</au><au>Yang, Dawei</au><au>Zhuang, Xuenan</au><au>Yu, Honghua</au><au>Hu, Yunyan</au><au>Zhang, Yan</au><au>Yang, Cheng</au><au>He, Miao</au><au>Zhang, Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screening for diabetic retinopathy in diabetic patients with a mydriasis-free, full-field flicker electroretinogram recording device</atitle><jtitle>Documenta ophthalmologica</jtitle><stitle>Doc Ophthalmol</stitle><addtitle>Doc Ophthalmol</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>140</volume><issue>3</issue><spage>211</spage><epage>220</epage><pages>211-220</pages><issn>0012-4486</issn><eissn>1573-2622</eissn><abstract>Purpose
To investigate the accuracy of the RETeval full-field flicker ERG in the screening of diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) and to determine a suitable range of DR diagnostic reference for patients with type 2 diabetes mellitus (T2DM).
Methods
This was a cross-sectional study involving 172 subjects with T2DM, including 71 subjects without clinically detectable DR (NDR), 25 subjects with mild non-proliferative diabetic retinopathy (NPDR), 24 subjects with moderate NPDR, 27 subjects with severe NPDR and 25 subjects with proliferative diabetic retinopathy (PDR). All the subjects underwent a full-field flicker ERG using the RETeval device (DR assessment protocol), which is a mydriasis-free, full-field electroretinogram (ERG) recording system. The performance of the DR assessment protocol in detecting the DR (including mild NPDR, moderate NPDR, severe NPDR and PDR) and VTDR was analyzed with the receiver operating characteristic (ROC) curve.
Results
For the detection of DR (mild NPDR, moderate NPDR, severe NPDR, PDR), the area under the ROC curve was 0.867 (
p
< 0.001, 95% CI 0.814–0.920), and the best cutoff value for DR was determined to be 20.75, with a sensitivity of 80.2% and specificity of 81.7%. Meanwhile, for the detection of VTDR, the area under the ROC curve was 0.965 (
p
< 0.001, 95% CI 0.941–0.989), and the best cutoff value was set to 23.05, with a sensitivity of 94.6% and a specificity of 88.8%.
Conclusion
The DR assessment protocol in RETeval device was effective in screening for DR (mild NPDR, moderate NPDR, severe NPDR, PDR) and VTDR in patients with diabetes. It could be helpful in referring and managing patients with T2DM in primary healthcare setting. However, caution should be taken that optimal cutoff value of DR assessment protocol may vary in different ethnic populations.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31720980</pmid><doi>10.1007/s10633-019-09734-2</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0454-8001</orcidid></addata></record> |
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| subjects | Diabetes Diabetes mellitus (non-insulin dependent) Diabetic retinopathy Electroretinograms Medicine Medicine & Public Health Ophthalmology Original Research Article Retina Retinopathy |
| title | Screening for diabetic retinopathy in diabetic patients with a mydriasis-free, full-field flicker electroretinogram recording device |
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