Prognostic value of the preoperative prognostic nutritional index in oldest-old patients with colorectal cancer

Background The prognostic nutritional index (PNI), which is calculated using serum albumin and the peripheral lymphocyte count, is a simple and useful score for predicting the prognosis in patients with various cancers. The correlation between the preoperative PNI and long-term outcomes is unclear i...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2020-05, Vol.50 (5), p.449-459
Main Authors: Tominaga, Tetsuro, Nonaka, Takashi, Hisanaga, Makoto, Fukuda, Akiko, Tanoue, Yukinori, Yoshimoto, Takafumi, Hidaka, Shigekazu, Sawai, Terumitsu, Nagayasu, Takeshi
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Original Article
Surgery
Surgical Oncology
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Summary:Background The prognostic nutritional index (PNI), which is calculated using serum albumin and the peripheral lymphocyte count, is a simple and useful score for predicting the prognosis in patients with various cancers. The correlation between the preoperative PNI and long-term outcomes is unclear in oldest-old patients with colorectal cancer. Methods A total of 84 consecutive patients ≥ 85 years old who underwent resection for primary colon adenocarcinoma at our institution between April 2008 and March 2017 were retrospectively reviewed. The cut-off value of the PNI for predicting the relapse-free survival (RFS) was 42.4 on a receiver operating characteristic curve analysis. The clinical characteristics and markers of systemic inflammation were then compared between patients with a low PNI (PNI 
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-019-01910-w