Effects of Probiotics on Intestinal Failure–Associated Liver Disease in Adult Patients Receiving Prolonged Parenteral Support: A Tertiary Care Center Experience

Background It has been hypothesized that dysbiosis plays a significant role in the pathogenesis of intestinal failure–associated liver disease (IFALD). Therefore, we aimed to investigate the effect of probiotics on IFALD in patients receiving parenteral support, namely home parenteral nutrition (HPN...

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Published in:Nutrition in clinical practice 2020-06, Vol.35 (3), p.454-463
Main Authors: Alomari, Mohammad, Nusairat, Leen, Al Momani, Laith, Chadalavada, Pravallika, Covut, Fahrettin, Olayan, May, Young, Mark, Romero‐Marrero, Carlos
Format: Article
Language:English
Subjects:
Adult
dysbiosis
Female
Humans
Intestinal Diseases - complications
Intestinal Diseases - microbiology
Intestinal Diseases - pathology
intestinal failure
Intestine, Small - pathology
liver disease
Liver Diseases - epidemiology
Liver Diseases - etiology
Liver Diseases - therapy
Male
Middle Aged
Nursing
parenteral nutrition
Parenteral Nutrition - methods
probiotics
Probiotics - therapeutic use
Retrospective Studies
short bowel syndrome
Short Bowel Syndrome - complications
Tertiary Care Centers
Treatment Outcome
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Summary:Background It has been hypothesized that dysbiosis plays a significant role in the pathogenesis of intestinal failure–associated liver disease (IFALD). Therefore, we aimed to investigate the effect of probiotics on IFALD in patients receiving parenteral support, namely home parenteral nutrition (HPN) and home intravenous fluids (HIVFs). Methods We retrospectively reviewed charts of patients with intestinal failure who received HPN or HIVF for >2 weeks at our tertiary center between January 2005 and August 2016. We excluded patients
ISSN:0884-5336
1941-2452
DOI:10.1002/ncp.10437