Tumor Volume Useful Beyond Classic Criteria in Selecting Larynx Cancers For Preservation Therapy

Objective To investigate the association between tumor volume and locoregional failure (LRF) after concurrent chemoradiation (CCRT) for locally advanced larynx cancer (LC). Methods This is a retrospective cohort study from 2009 to 2014 identified from an institutional review board–approved registry....

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Bibliographic Details
Published in:The Laryngoscope 2020-10, Vol.130 (10), p.2372-2377
Main Authors: Sharrett, Jonathan M., Ward, Matthew C., Murray, Eric, Scharpf, Joseph, Lamarre, Eric D., Prendes, Brandon L., Lorenz, Robert R., Burkey, Brian B., Koyfman, Shlomo A., Woody, Neil M., Greskovich, John F., Adelstein, David J., Geiger, Jessica L., Joshi, Nikhil P.
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - diagnostic imaging
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
chemoradiation
Chemoradiotherapy - methods
Female
Humans
Investigations
Laryngeal cancer
Laryngeal Neoplasms - diagnostic imaging
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - therapy
Larynx
Larynx cancer
larynx preservation
Male
Middle Aged
Neoplasm Staging
Ostomy
Patient Selection
Registries
Retrospective Studies
Tomography, X-Ray Computed
Tumor Burden
tumor volume
Tumors
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Summary:Objective To investigate the association between tumor volume and locoregional failure (LRF) after concurrent chemoradiation (CCRT) for locally advanced larynx cancer (LC). Methods This is a retrospective cohort study from 2009 to 2014 identified from an institutional review board–approved registry. Fifty‐nine of 68 patients with locally advanced larynx cancer treated with definitive CCRT who had available imaging for review were identified. The main endpoint to be assessed was the association between gross tumor volumes (GTV; T = total, P = primary, N = nodal) and LRF. Receiver operative characteristic (ROC) curves were used to investigate diagnostic accuracy. Results Twenty LRFs were observed, resulting in a 2‐year LRF rate of 39% (95% CI, 23–52%). On UVA, the GTV‐T (P = .01), GTV‐P (P = .05), and GTV‐N (P = .04) were statistically significant predictors of LRF. Furthermore, age, smoking status, N‐stage, larynx subsite, and tracheostomy/feeding tube dependence were potentially associated with LRF (P 
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.28396