Predisposing and precipitating risk factors for delirium in palliative care patients

Delirium is a common complication in palliative care patients, especially in the terminal phase of the illness. To date, evidence regarding risk factors and prognostic outcomes of delirium in this vulnerable population remains sparse. In this prospective observational cohort study at a tertiary care...

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Bibliographic Details
Published in:Palliative & supportive care 2020-08, Vol.18 (4), p.437-446
Main Authors: Seiler, Annina, Schubert, Maria, Hertler, Caroline, Schettle, Markus, Blum, David, Guckenberger, Matthias, Weller, Michael, Ernst, Jutta, von Känel, Roland, Boettger, Soenke
Format: Article
Language:English
Subjects:
Alzheimer's disease
Caregivers
Cognitive ability
Consciousness
Delirium
Dementia
Disease prevention
Edema
Electrolytes
Epidemiology
Hospitals
Medical prognosis
Mental disorders
Metabolism
Original Article
Palliative care
Patients
Risk factors
Sepsis
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Summary:Delirium is a common complication in palliative care patients, especially in the terminal phase of the illness. To date, evidence regarding risk factors and prognostic outcomes of delirium in this vulnerable population remains sparse. In this prospective observational cohort study at a tertiary care center, 410 palliative care patients were included. Simple and multiple logistic regression models were used to identify associations between predisposing and precipitating factors and delirium in palliative care patients. The prevalence of delirium in this palliative care cohort was 55.9% and reached 93% in the terminally ill. Delirium was associated with prolonged hospitalization (p < 0.001), increased care requirements (p < 0.001) and health care costs (p < 0.001), requirement for institutionalization (OR 0.11; CI 0.069-0.171; p < 0.001), and increased mortality (OR 18.29; CI 8.918-37.530; p < 0.001). Predisposing factors for delirium were male gender (OR 2.19; CI 1.251-3.841; p < 0.01), frailty (OR 15.28; CI 5.885-39.665; p < 0.001), hearing (OR 3.52; CI 1.721-7.210; p < 0.001), visual impairment (OR 3.15; CI 1.765-5.607; p < 0.001), and neoplastic brain disease (OR 3.63; CI 1.033-12.771; p < 0.05). Precipitating factors for delirium were acute renal failure (OR 6.79; CI 1.062-43.405; p < 0.05) and pressure sores (OR 3.66; CI 1.102-12.149; p < 0.05). Our study identified several predisposing and precipitating risk factors for delirium in palliative care patients, some of which can be targeted early and modified to reduce symptom burden.
ISSN:1478-9515
1478-9523
DOI:10.1017/S1478951519000919