Adenosine STEPs on synaptic function: An Editorial for 'The activity of the STriatal-enriched protein tyrosine phosphatase in neuronal cells is modulated by adenosine A2A receptor on' page 284

This is an Editorial Highlight of a manuscript by Mallozzi et al. (2019) in the current issue of the Journal of Neurochemistry, in which the authors detail the biochemical pathway that leads to synaptic depression by cocaine. This pathway requires the adenosine A receptor and STEP phosphatases. Acti...

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Bibliographic Details
Published in:Journal of neurochemistry 2020-02, Vol.152 (3), p.270-272
Main Author: Yasuda, Robert P
Format: Article
Language:English
Subjects:
Activation
Adenosine
Calcium
Calcium (intracellular)
Cocaine
Dephosphorylation
Glutamic acid receptors (ionotropic)
Internalization
Mental disorders
Receptors
Synaptic depression
Therapeutic targets
Tyrosine
Citations: Items that this one cites
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Summary:This is an Editorial Highlight of a manuscript by Mallozzi et al. (2019) in the current issue of the Journal of Neurochemistry, in which the authors detail the biochemical pathway that leads to synaptic depression by cocaine. This pathway requires the adenosine A receptor and STEP phosphatases. Activation of the adenosine A receptor leads to an increase in intracellular calcium, activation of STEP by dephosphorylation, inhibition of excitatory ionotropic glutamate receptors by dephosphorylation of phospho-tyrosine residues and subsequent internalization of the ionotropic glutamate receptors. This adenosine A receptor pathway could lead to potential drug targets for neurologic and neuropsychiatric disorders.
ISSN:0022-3042
1471-4159
DOI:10.1111/jnc.14901