Clinical utility of FibroScan as a non‐invasive diagnostic test for primary biliary cholangitis

Background and Aim Primary biliary cholangitis (PBC) is a chronic, slowly progressive, autoimmune liver disease. Some PBC patients display disease progression regardless of medical treatment. Therefore, it is important to accurately diagnose the clinical stage of PBC. This study investigated clinica...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2020-07, Vol.35 (7), p.1208-1214
Main Authors: Joshita, Satoru, Yamashita, Yuki, Sugiura, Ayumi, Uehara, Takeshi, Usami, Yoko, Yamazaki, Tomoo, Fujimori, Naoyuki, Matsumoto, Akihiro, Tanaka, Eiji, Umemura, Takeji
Format: Article
Language:English
Subjects:
Aspartate aminotransferase
Cholangitis
Cirrhosis
Diagnostic tests
FibroScan
Glycosylation
Liver cirrhosis
Liver diseases
Liver stiffness measurement
M2BPGi
Medical treatment
Nakanuma's classification
Patients
Primary biliary cholangitis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Aim Primary biliary cholangitis (PBC) is a chronic, slowly progressive, autoimmune liver disease. Some PBC patients display disease progression regardless of medical treatment. Therefore, it is important to accurately diagnose the clinical stage of PBC. This study investigated clinical merits of vibration‐controlled transient elastography using FibroScan for assessing disease stage in PBC. Methods A total of 74 treatment‐naïve PBC patients (84% female, median age: 64 years), 69 of whom having undergone histological assessment and five clinically diagnosed as at the cirrhosis stage, were enrolled for clinical comparisons of liver stiffness measurement (LSM) with other established indices. Results The number of patients with Nakanuma stages 1, 2, 3, and 4 was 18, 33, 17, and 6, respectively. The median LSM values for Nakanuma stages 1, 2, 3, and 4 were 5.05, 5.90, 8.90, and 23.70 kPa, respectively, and correlated significantly with disease progression based on Nakanuma's classification (r = 0.501, P 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.14929