Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device

Recent pre-clinical studies have demonstrated the potential of combining chemotherapy and sonodynamic therapy for the treatment of pancreatic cancer. Oxygen-loaded magnetic microbubbles have been explored as a targeted delivery vehicle for this application. Despite preliminary positive results, a pr...

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Bibliographic Details
Published in:Journal of controlled release 2020-01, Vol.317, p.23-33
Main Authors: Beguin, Estelle, Gray, Michael D., Logan, Keiran A., Nesbitt, Heather, Sheng, Yingjie, Kamila, Sukanta, Barnsley, Lester C., Bau, Luca, McHale, Anthony P., Callan, John F., Stride, Eleanor
Format: Article
Language:English
Subjects:
Drug delivery
Magnetic targeting
Medical devices
Microbubbles
Sonodynamic therapy
Ultrasound
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Summary:Recent pre-clinical studies have demonstrated the potential of combining chemotherapy and sonodynamic therapy for the treatment of pancreatic cancer. Oxygen-loaded magnetic microbubbles have been explored as a targeted delivery vehicle for this application. Despite preliminary positive results, a previous study identified a significant practical challenge regarding the co-alignment of the magnetic and ultrasound fields. The aim of this study was to determine whether this challenge could be addressed through the use of a magnetic-acoustic device (MAD) combining a magnetic array and ultrasound transducer in a single unit, to simultaneously concentrate and activate the microbubbles at the target site. in vitro experiments were performed in tissue phantoms and followed by in vivo treatment of xenograft pancreatic cancer (BxPC-3) tumours in a murine model. In vitro, a 1.4-fold (p 
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2019.11.013