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Determining the Polymorphism Information Content of a molecular marker

•PIC measures molecular markers’ quality for genetic analyses.•There are several equations for PIC calculation.•We propose a simplified equation for PIC calculation for dominant markers. This review was carried out with the purpose of contributing to the discussion on the equations used in calculati...

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Published in:	Gene 2020-02, Vol.726, p.144175-144175, Article 144175
Main Authors:	Serrote, Caetano Miguel Lemos, Reiniger, Lia Rejane Silveira, Silva, Karol Buuron, Rabaiolli, Silvia Machado dos Santos, Stefanel, Charlene Moro
Format:	Article
Language:	English
Subjects:	Animals Genetic Markers - genetics Genetic studies Heterozygote Humans Marker quality PIC calculation Polymorphism Polymorphism, Genetic - genetics
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creator	Serrote, Caetano Miguel Lemos Reiniger, Lia Rejane Silveira Silva, Karol Buuron Rabaiolli, Silvia Machado dos Santos Stefanel, Charlene Moro
description	•PIC measures molecular markers’ quality for genetic analyses.•There are several equations for PIC calculation.•We propose a simplified equation for PIC calculation for dominant markers. This review was carried out with the purpose of contributing to the discussion on the equations used in calculating the Polymorphism Information Content (PIC) of molecular markers. PIC measures the ability of a marker to detect polymorphisms, and therefore has enormous importance in selecting markers for genetic studies. We perform a summary analysis of PIC and its difference in relation to heterozygosity, another parameter used to evaluate the quality of a marker, presenting and discussing the several equations registered in the literature for both dominant and codominant markers. Finally, we present a brief direction on estimating PIC for dominant markers.
doi_str_mv	10.1016/j.gene.2019.144175
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subjects	Animals Genetic Markers - genetics Genetic studies Heterozygote Humans Marker quality PIC calculation Polymorphism Polymorphism, Genetic - genetics
title	Determining the Polymorphism Information Content of a molecular marker
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