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A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas
Objective To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among wo...
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| Published in: | Pituitary 2020-04, Vol.23 (2), p.120-128 |
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| creator | Sant’ Anna, B. G. Musolino, N. R. C. Gadelha, M. R. Marques, C. Castro, M. Elias, P. C. L. Vilar, L. Lyra, R. Martins, M. R. A. Quidute, A. R. P. Abucham, J. Nazato, D. Garmes, H. M. Fontana, M. L. C. Boguszewski, C. L. Bueno, C. B. Czepielewski, M. A. Portes, E. S. Nunes-Nogueira, V. S. Ribeiro-Oliveira, A. Francisco, R. P. V. Bronstein, M. D. Glezer, A. |
| description | Objective
To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort.
Methods
The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study,
Results
We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases.
Conclusions
Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed. |
| doi_str_mv | 10.1007/s11102-019-01008-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2315092463</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2315092463</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-31b8fbe4f0704f1d94f1bf5eb4f5ea40e8bf7d2c93a91b459d1b044af8c868063</originalsourceid><addsrcrecordid>eNp9kUtLxTAQhYMovv-ACwm4cVOdNOlrqRdfILhRcBeSdHqNtOk1aYV7f7251ge4cJHJEL5zJswh5IjBGQMozgNjDNIEWBUPQJmsNsguywqeFAL4Zux5mSdcsOcdshfCK6wpLrbJDmdFWlaQ75L-gl56tbKtVY52YztYg27wSMMw1kuK76od1WDdnC48zp1yxmKg1tWjwZrqJTVKo5_3rXUYn-kiwtEg0Bflde8nYd8qEz36ToUDstWoNuDh171Pnq6vHme3yf3Dzd3s4j4xvMiGhDNdNhpFAwWIhtVVLLrJUItYlAAsdVPUqam4qpgWWVUzDUKopjRlXkLO98np5Bunv40YBtnZYLBtlcN-DDLlLIMqFTmP6Mkf9LUfvYu_i1SRQ5WlbG2YTpTxfQgeG7nwtlN-KRnIdRxyikPGOORnHHIVRcdf1qPusP6RfO8_AnwCwmK9K_S_s_-x_QC__JhA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2376095216</pqid></control><display><type>article</type><title>A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas</title><source>Springer Nature</source><creator>Sant’ Anna, B. G. ; Musolino, N. R. C. ; Gadelha, M. R. ; Marques, C. ; Castro, M. ; Elias, P. C. L. ; Vilar, L. ; Lyra, R. ; Martins, M. R. A. ; Quidute, A. R. P. ; Abucham, J. ; Nazato, D. ; Garmes, H. M. ; Fontana, M. L. C. ; Boguszewski, C. L. ; Bueno, C. B. ; Czepielewski, M. A. ; Portes, E. S. ; Nunes-Nogueira, V. S. ; Ribeiro-Oliveira, A. ; Francisco, R. P. V. ; Bronstein, M. D. ; Glezer, A.</creator><creatorcontrib>Sant’ Anna, B. G. ; Musolino, N. R. C. ; Gadelha, M. R. ; Marques, C. ; Castro, M. ; Elias, P. C. L. ; Vilar, L. ; Lyra, R. ; Martins, M. R. A. ; Quidute, A. R. P. ; Abucham, J. ; Nazato, D. ; Garmes, H. M. ; Fontana, M. L. C. ; Boguszewski, C. L. ; Bueno, C. B. ; Czepielewski, M. A. ; Portes, E. S. ; Nunes-Nogueira, V. S. ; Ribeiro-Oliveira, A. ; Francisco, R. P. V. ; Bronstein, M. D. ; Glezer, A.</creatorcontrib><description>Objective
To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort.
Methods
The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study,
Results
We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases.
Conclusions
Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.</description><identifier>ISSN: 1386-341X</identifier><identifier>EISSN: 1573-7403</identifier><identifier>DOI: 10.1007/s11102-019-01008-z</identifier><identifier>PMID: 31728906</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abortion, Spontaneous - pathology ; Adenoma ; Adolescent ; Adult ; Aged ; Birth weight ; Cabergoline - therapeutic use ; Congenital defects ; Dopamine Agonists - therapeutic use ; Endocrinology ; Female ; Fetuses ; Human Physiology ; Humans ; Hyperprolactinemia - pathology ; Low birth weight ; Medicine ; Medicine & Public Health ; Middle Aged ; Miscarriage ; Pituitary ; Pituitary gland ; Pregnancy ; Pregnancy Complications, Neoplastic ; Prolactin ; Prolactinoma - pathology ; Retrospective Studies ; Tumors ; Young Adult</subject><ispartof>Pituitary, 2020-04, Vol.23 (2), p.120-128</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Pituitary is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-31b8fbe4f0704f1d94f1bf5eb4f5ea40e8bf7d2c93a91b459d1b044af8c868063</citedby><cites>FETCH-LOGICAL-c375t-31b8fbe4f0704f1d94f1bf5eb4f5ea40e8bf7d2c93a91b459d1b044af8c868063</cites><orcidid>0000-0002-5478-0431</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31728906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sant’ Anna, B. G.</creatorcontrib><creatorcontrib>Musolino, N. R. C.</creatorcontrib><creatorcontrib>Gadelha, M. R.</creatorcontrib><creatorcontrib>Marques, C.</creatorcontrib><creatorcontrib>Castro, M.</creatorcontrib><creatorcontrib>Elias, P. C. L.</creatorcontrib><creatorcontrib>Vilar, L.</creatorcontrib><creatorcontrib>Lyra, R.</creatorcontrib><creatorcontrib>Martins, M. R. A.</creatorcontrib><creatorcontrib>Quidute, A. R. P.</creatorcontrib><creatorcontrib>Abucham, J.</creatorcontrib><creatorcontrib>Nazato, D.</creatorcontrib><creatorcontrib>Garmes, H. M.</creatorcontrib><creatorcontrib>Fontana, M. L. C.</creatorcontrib><creatorcontrib>Boguszewski, C. L.</creatorcontrib><creatorcontrib>Bueno, C. B.</creatorcontrib><creatorcontrib>Czepielewski, M. A.</creatorcontrib><creatorcontrib>Portes, E. S.</creatorcontrib><creatorcontrib>Nunes-Nogueira, V. S.</creatorcontrib><creatorcontrib>Ribeiro-Oliveira, A.</creatorcontrib><creatorcontrib>Francisco, R. P. V.</creatorcontrib><creatorcontrib>Bronstein, M. D.</creatorcontrib><creatorcontrib>Glezer, A.</creatorcontrib><title>A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas</title><title>Pituitary</title><addtitle>Pituitary</addtitle><addtitle>Pituitary</addtitle><description>Objective
To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort.
Methods
The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study,
Results
We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases.
Conclusions
Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.</description><subject>Abortion, Spontaneous - pathology</subject><subject>Adenoma</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Birth weight</subject><subject>Cabergoline - therapeutic use</subject><subject>Congenital defects</subject><subject>Dopamine Agonists - therapeutic use</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fetuses</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Hyperprolactinemia - pathology</subject><subject>Low birth weight</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Miscarriage</subject><subject>Pituitary</subject><subject>Pituitary gland</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Neoplastic</subject><subject>Prolactin</subject><subject>Prolactinoma - pathology</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1386-341X</issn><issn>1573-7403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kUtLxTAQhYMovv-ACwm4cVOdNOlrqRdfILhRcBeSdHqNtOk1aYV7f7251ge4cJHJEL5zJswh5IjBGQMozgNjDNIEWBUPQJmsNsguywqeFAL4Zux5mSdcsOcdshfCK6wpLrbJDmdFWlaQ75L-gl56tbKtVY52YztYg27wSMMw1kuK76od1WDdnC48zp1yxmKg1tWjwZrqJTVKo5_3rXUYn-kiwtEg0Bflde8nYd8qEz36ToUDstWoNuDh171Pnq6vHme3yf3Dzd3s4j4xvMiGhDNdNhpFAwWIhtVVLLrJUItYlAAsdVPUqam4qpgWWVUzDUKopjRlXkLO98np5Bunv40YBtnZYLBtlcN-DDLlLIMqFTmP6Mkf9LUfvYu_i1SRQ5WlbG2YTpTxfQgeG7nwtlN-KRnIdRxyikPGOORnHHIVRcdf1qPusP6RfO8_AnwCwmK9K_S_s_-x_QC__JhA</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Sant’ Anna, B. G.</creator><creator>Musolino, N. R. C.</creator><creator>Gadelha, M. R.</creator><creator>Marques, C.</creator><creator>Castro, M.</creator><creator>Elias, P. C. L.</creator><creator>Vilar, L.</creator><creator>Lyra, R.</creator><creator>Martins, M. R. A.</creator><creator>Quidute, A. R. P.</creator><creator>Abucham, J.</creator><creator>Nazato, D.</creator><creator>Garmes, H. M.</creator><creator>Fontana, M. L. C.</creator><creator>Boguszewski, C. L.</creator><creator>Bueno, C. B.</creator><creator>Czepielewski, M. A.</creator><creator>Portes, E. S.</creator><creator>Nunes-Nogueira, V. S.</creator><creator>Ribeiro-Oliveira, A.</creator><creator>Francisco, R. P. V.</creator><creator>Bronstein, M. 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C. ; Gadelha, M. R. ; Marques, C. ; Castro, M. ; Elias, P. C. L. ; Vilar, L. ; Lyra, R. ; Martins, M. R. A. ; Quidute, A. R. P. ; Abucham, J. ; Nazato, D. ; Garmes, H. M. ; Fontana, M. L. C. ; Boguszewski, C. L. ; Bueno, C. B. ; Czepielewski, M. A. ; Portes, E. S. ; Nunes-Nogueira, V. S. ; Ribeiro-Oliveira, A. ; Francisco, R. P. V. ; Bronstein, M. 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G.</creatorcontrib><creatorcontrib>Musolino, N. R. C.</creatorcontrib><creatorcontrib>Gadelha, M. R.</creatorcontrib><creatorcontrib>Marques, C.</creatorcontrib><creatorcontrib>Castro, M.</creatorcontrib><creatorcontrib>Elias, P. C. L.</creatorcontrib><creatorcontrib>Vilar, L.</creatorcontrib><creatorcontrib>Lyra, R.</creatorcontrib><creatorcontrib>Martins, M. R. A.</creatorcontrib><creatorcontrib>Quidute, A. R. P.</creatorcontrib><creatorcontrib>Abucham, J.</creatorcontrib><creatorcontrib>Nazato, D.</creatorcontrib><creatorcontrib>Garmes, H. M.</creatorcontrib><creatorcontrib>Fontana, M. L. C.</creatorcontrib><creatorcontrib>Boguszewski, C. L.</creatorcontrib><creatorcontrib>Bueno, C. B.</creatorcontrib><creatorcontrib>Czepielewski, M. A.</creatorcontrib><creatorcontrib>Portes, E. S.</creatorcontrib><creatorcontrib>Nunes-Nogueira, V. S.</creatorcontrib><creatorcontrib>Ribeiro-Oliveira, A.</creatorcontrib><creatorcontrib>Francisco, R. P. 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G.</au><au>Musolino, N. R. C.</au><au>Gadelha, M. R.</au><au>Marques, C.</au><au>Castro, M.</au><au>Elias, P. C. L.</au><au>Vilar, L.</au><au>Lyra, R.</au><au>Martins, M. R. A.</au><au>Quidute, A. R. P.</au><au>Abucham, J.</au><au>Nazato, D.</au><au>Garmes, H. M.</au><au>Fontana, M. L. C.</au><au>Boguszewski, C. L.</au><au>Bueno, C. B.</au><au>Czepielewski, M. A.</au><au>Portes, E. S.</au><au>Nunes-Nogueira, V. S.</au><au>Ribeiro-Oliveira, A.</au><au>Francisco, R. P. V.</au><au>Bronstein, M. D.</au><au>Glezer, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas</atitle><jtitle>Pituitary</jtitle><stitle>Pituitary</stitle><addtitle>Pituitary</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>23</volume><issue>2</issue><spage>120</spage><epage>128</epage><pages>120-128</pages><issn>1386-341X</issn><eissn>1573-7403</eissn><abstract>Objective
To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort.
Methods
The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study,
Results
We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases.
Conclusions
Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31728906</pmid><doi>10.1007/s11102-019-01008-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5478-0431</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1386-341X |
| ispartof | Pituitary, 2020-04, Vol.23 (2), p.120-128 |
| issn | 1386-341X 1573-7403 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2315092463 |
| source | Springer Nature |
| subjects | Abortion, Spontaneous - pathology Adenoma Adolescent Adult Aged Birth weight Cabergoline - therapeutic use Congenital defects Dopamine Agonists - therapeutic use Endocrinology Female Fetuses Human Physiology Humans Hyperprolactinemia - pathology Low birth weight Medicine Medicine & Public Health Middle Aged Miscarriage Pituitary Pituitary gland Pregnancy Pregnancy Complications, Neoplastic Prolactin Prolactinoma - pathology Retrospective Studies Tumors Young Adult |
| title | A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas |
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