Serum amyloid A and C-reactive protein levels and erythrocyte sedimentation rate are important indicators in hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a chronic disabling inflammatory disease of the follicular unit especially affecting apocrine gland-bearing skin areas. Little is known about systemic inflammatory complications of the disease. This study aimed to evaluate systemic inflammation in patients with HS by...

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Bibliographic Details
Published in:Archives of Dermatological Research 2020-05, Vol.312 (4), p.255-262
Main Authors: Akdogan, Neslihan, Dogan, Sibel, Incel-Uysal, Pinar, Karabulut, Erdem, Topcuoglu, Canan, Yalcin, Basak, Atakan, Nilgun
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Blood Glucose - analysis
Blood Sedimentation
Body Mass Index
C-Reactive Protein - analysis
Case-Control Studies
Cigarette Smoking - blood
Cigarette Smoking - epidemiology
Cigarette Smoking - immunology
Dermatology
Female
Hidradenitis Suppurativa - blood
Hidradenitis Suppurativa - diagnosis
Hidradenitis Suppurativa - immunology
Humans
Inflammation - blood
Inflammation - diagnosis
Inflammation - immunology
Lipids - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Reference Values
Risk Factors
Serum Amyloid A Protein - analysis
Severity of Illness Index
Waist Circumference
Young Adult
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Summary:Hidradenitis suppurativa (HS) is a chronic disabling inflammatory disease of the follicular unit especially affecting apocrine gland-bearing skin areas. Little is known about systemic inflammatory complications of the disease. This study aimed to evaluate systemic inflammation in patients with HS by assessing serum amyloid A protein (SAA) and C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR) and to identify potential risk factors for HS. Forty-four patients (M/F: 28/16) and 44 age- and sex-matched controls (M/F: 28/16) were enrolled. Demographic, clinical, laboratory, and therapeutic data, including smoking status, body mass index (BMI), waist circumference (WC), serum fasting lipid profile, fasting blood glucose, SAA, and CRP levels, and ESR were assessed. Associations were investigated by univariate and multivariate analyses. Patients with HS showed significantly higher levels of pack-years of cigarette smoking, weight, BMI, and WC ( P  = 0.01, P  
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-019-02014-8