A seven long-noncoding RNA signature predicts prognosis of lung squamous cell carcinoma

• Published in: Biomarkers in medicine 2020-01, Vol.14 (1), p.53-63
• Main Authors: Li, Shuai, Teng, Yue, Yuan, Min-Jie, Ma, Ting-Ting, Ma, Jian, Gao, Xu-Jie
• Format: Article
• Language: English
• Subjects: Angiogenesis; Apoptosis; biomarker; Biomarkers; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell migration; Data analysis; Datasets; Female; Follow-Up Studies; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; gene signature; Genomes; Humans; lncRNA; Lung cancer; Lung carcinoma; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; lung SCC; Male; MAP kinase; Medical prognosis; Middle Aged; mRNA; Prognosis; Proteins; Regression analysis; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Squamous cell carcinoma; Survival analysis; Survival Rate
• ISSN: 1752-0363; 1752-0371
• DOI: 10.2217/bmm-2019-0282

This study profiled differentially expressed long noncoding RNAs (lncRNAs) in lung squamous cell carcinoma (LSCC) to predict LSCC overall survival (OS) using The Cancer Genome Atlas data. The RNA-seq and clinical dataset of 475 LSCC patients was retrieved from The Cancer Genome Atlas database and statistically analyzed. There were 67 upregulated and 32 downregulated lncRNAs in LSCCs and 12 lncRNAs associated with OS. The seven-lncRNA signature was associated with poor OS and RP11-150O12.6 and CTA-384D8.35 were associated with better OS (p < 0.001). The seven lncRNAs-mRNA interaction network analysis showed their association with 187 protein-coding genes for cancer development, cell migration, adhesion, proliferation, apoptosis, angiogenesis and the MAPK signaling pathways. This seven-lncRNA signature is useful to predict LSCC OS.