Trichoblastic carcinosarcoma: A case report and literature review

Trichoblastic carcinosarcoma is a rare biphasic adnexal neoplasm. This case report chronicals the eighth occurrence of this tumor published in the English literature and provides a review of the prior publications. Clinically, this tumor presents as an isolated, rapidly growing lesion in elderly pat...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2020-04, Vol.47 (4), p.409-413
Main Authors: Underwood, Caroline I. M., Mansoori, Parisa, Selim, Angelica M., Al‐Rohil, Rami N.
Format: Article
Language:English
Subjects:
Aged
Basal cells
Carcinosarcoma - diagnosis
Carcinosarcoma - metabolism
Carcinosarcoma - pathology
Case reports
cutaneous carcinosarcoma
Dermis - metabolism
Dermis - pathology
Geriatrics
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - pathology
Humans
Literature reviews
Male
malignant adnexal neoplasm
Mesenchyme
Metastases
Skin Neoplasms - diagnosis
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
trichoblastic carcinosarcoma
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Summary:Trichoblastic carcinosarcoma is a rare biphasic adnexal neoplasm. This case report chronicals the eighth occurrence of this tumor published in the English literature and provides a review of the prior publications. Clinically, this tumor presents as an isolated, rapidly growing lesion in elderly patients and is usually cured by complete surgical excision, with no evidence of recurrence or metastasis at follow‐up (7/8 cases). Histopathologically, trichoblastic carcinosarcoma is dermal‐based, with an epithelial component of basal cells and a mesenchymal component of spindle cells, both of which display malignant features. In addition to a morphologic description of trichoblastic carcinosarcoma, a discussion of the differential diagnoses, including other biphasic neoplasms, is also included. The small number of cases of trichoblastic carcinosarcoma is most likely secondary to under‐recognition and underreporting and a larger case volume is needed to more accurately assess the clinical course and treatment strategies.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13614