Treatment Strategy for Distant Synchronous Metastatic Head and Neck Squamous Cell Carcinoma

Purpose of Review Management of metastatic head and neck squamous cell cancers (HNSCC) can be challenging. This review gives an insight of current treatment options for patients with synchronous metastatic HNSCC and suggests a therapeutic algorithm. Recent Findings With the rise of novel therapeutic...

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Bibliographic Details
Published in:Current oncology reports 2019-11, Vol.21 (11), p.102-8, Article 102
Main Authors: Tang, Eliane, Lahmi, Lucien, Meillan, Nicolas, Pietta, Gianandrea, Albert, Sébastien, Maingon, Philippe
Format: Article
Language:English
Subjects:
Algorithms
Head & neck cancer
Head and Neck Cancers (EY Hanna
Medicine
Medicine & Public Health
Metastases
Metastasis
Oncology
Patients
Radiation therapy
Section Editor
Squamous cell carcinoma
Surgery
Topical Collection on Head and Neck Cancers
Tumors
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Summary:Purpose of Review Management of metastatic head and neck squamous cell cancers (HNSCC) can be challenging. This review gives an insight of current treatment options for patients with synchronous metastatic HNSCC and suggests a therapeutic algorithm. Recent Findings With the rise of novel therapeutic techniques and medications, many treatment options for both locoregional and distant metastatic disease have become available. The evolving paradigm of metastatic disease now integrates the concept of oligometastatic disease. On top of systemic treatments, patients with low metastatic burden can benefit from curative approaches such as local therapies (surgery, radiotherapy) directed to either primary tumour and distant metastasis. However, data integrating these considerations in the management of metastatic HNSCC is still lacking. Summary Based on this algorithm, we can provide a tailored treatment to each patient with synchronous metastatic HNSCC, according to their age, general condition and metastatic burden.
ISSN:1523-3790
1534-6269
DOI:10.1007/s11912-019-0856-5