Kidney function and cognitive impairment among older hospitalized patients: a comparison of four glomerular filtration rate equations

Background The relationship between the estimated glomerular filtration rate (eGFR) and cognitive impairment may change as a function of the equation used. We aimed at investigating the association between four different eGFR equations and cognitive impairment among older hospitalized patients. Meth...

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Bibliographic Details
Published in:Aging clinical and experimental research 2020-05, Vol.32 (5), p.841-850
Main Authors: Pierpaoli, Elisa, Fabi, Katia, Lenci, Federica Francesca, Ricci, Maddalena, Di Rosa, Mirko, Onder, Graziano, Volpato, Stefano, Ruggiero, Carmelinda, Cherubini, Antonio, Corsonello, Andrea, Lattanzio, Fabrizia
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Apraxia
Cognitive ability
Cognitive Dysfunction - etiology
Collaboration
Female
Geriatrics
Geriatrics/Gerontology
Glomerular Filtration Rate
Hospitalization
Humans
Internal medicine
Kidney diseases
Male
Medicine
Medicine & Public Health
Memory
Older people
Original Article
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - physiopathology
ROC Curve
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Summary:Background The relationship between the estimated glomerular filtration rate (eGFR) and cognitive impairment may change as a function of the equation used. We aimed at investigating the association between four different eGFR equations and cognitive impairment among older hospitalized patients. Methods Our series consisted of 795 older patients consecutively admitted to 7 geriatric and internal medicine acute care wards. The eGFR was calculated by Chronic Kidney Disease Epidemiologic Collaboration (CKD-EPI), Cockcroft-Gault (CG), Berlin Initiative Study (BIS) and Full Age Spectrum (FAS) equations. Study outcomes were total Mini Mental State Examination (MMSE) 
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-019-01405-1