Combinatorial Oxytocin Neuropharmacology in Social Cognition

The efficacy and reliability of using intranasal oxytocin (OT) to clinically enhance social functions remains undependable. We discuss the potential benefit of concurrent administration of OT and naloxone (NAL) to robustly modulate social behavior. We further suggest that combinatorial neuropharmaco...

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Bibliographic Details
Published in:Trends in cognitive sciences 2020-01, Vol.24 (1), p.8-12
Main Authors: Fan, Siqi, Weinberg-Wolf, Hannah, Piva, Matthew, Dal Monte, Olga, Chang, Steve W.C.
Format: Article
Language:English
Subjects:
Autism Spectrum Disorder - therapy
autism spectrum disorders
combinatorial neuropharmacology
Humans
naloxone
Neuropharmacology
oxytocin
Oxytocin - administration & dosage
Oxytocin - therapeutic use
Reproducibility of Results
serotonin
Social Behavior
Social Cognition
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Summary:The efficacy and reliability of using intranasal oxytocin (OT) to clinically enhance social functions remains undependable. We discuss the potential benefit of concurrent administration of OT and naloxone (NAL) to robustly modulate social behavior. We further suggest that combinatorial neuropharmacology approaches should exploit the interactions between OT and serotonin to regulate social functions.
ISSN:1364-6613
1879-307X
DOI:10.1016/j.tics.2019.10.004