Intercontinental collaborative experience with abdominal, retroperitoneal and pelvic schwannomas

• Published in: British journal of surgery 2020-03, Vol.107 (4), p.452-463
• Main Authors: Monteiro De Barros, J., Hodson, J., Glasbey, J., Massey, R., Rintoul‐Hoad, O., Chetan, M., Desai, A., Almond, L. M., Gourevitch, D., Ford, S. J., Strauss, D., Smith, H., Hayes, A., Cardona, K., Lopez‐Aguiar, A., Johnson, A., Swallow, C., Burtenshaw, S., Nessim, C., Weng, R., Purgin, B., Gronchi, A., Fiore, M., Callegaro, D., Raut, C. P., Fairweather, M., Bagaria, S., Novak, M., Gyorki, D., Reid, F., Mullinax, J., Gonzalez, R. J., Van Coevorden, F., Van Houdt, W., Haas, R. L. M., Van Boven, H., Heeres, B.
• Format: Article
• Language: English
• Subjects: Abdomen; Abdominal surgery; Collaboration; Tumors
• ISSN: 0007-1323; 1365-2168
• DOI: 10.1002/bjs.11376

Abstract Background Schwannomas are rare tumours that pose a significant management challenge in the abdomen, retroperitoneum and pelvis. No data are available to inform management strategy. Methods A collaborative international cohort study, across specialist sarcoma units, was conducted to include adults presenting between 2000 and 2017 with histopathologically confirmed schwannomas within the abdomen, retroperitoneum or pelvis. Results Of 485 patients across 12 centres, 38 (7·8 per cent) were discharged without follow-up, 199 (41·0 per cent) underwent early resection and 248 (51·1 per cent) had radiological monitoring. Of these 248 patients, 96 (38·7 per cent) eventually had surgery, giving an overall resection rate of 60·8 per cent (295 of 485). At baseline, median tumour volume was 90·1 (i.q.r. 26·5–262·0) cm3. The estimated growth rate was 10·5 (95 per cent c.i. 9·4 to 11·6) per cent per year, and was consistent in the short term (within 2 years of diagnosis) and long term (beyond 2 years) (ρ = 0·405, P = 0·021). A decision to operate was more common in symptomatic patients (P < 0·001) and for rapidly growing tumours (growth rate more than 20 per cent per year) (P = 0·025). R0/R1 resection was achieved in 91·6 per cent of patients (263 of 287). Kaplan–Meier long-term recurrence rates after R0/R1 resection were 2·3 and 6·7 per cent at 3 and 5 years respectively. Conclusion Specific recommendations include: indications for early surgery, prediction of growth from radiological monitoring, promotion of selective submacroscopic resection and cessation of postoperative imaging surveillance. Graphical Abstract Schwannomas present a significant management challenge, and surgery can result in morbidity. Individualized growth rates predicted after a period of radiological monitoring can help guide decision-making. There is no role for surveillance after resection. Graphical Abstract Practical guidelines