Functional significance of post-myocardial infarction inflammation evaluated by 18F-fluorodeoxyglucose imaging in swine model

The aim of the study was to investigate the relationship between post-myocardial infarction (MI) inflammation and left ventricular (LV) remodeling in a swine model by 18F-fluorodeoxyglucose (FDG) imaging. MI was induced in swine by balloon occlusion of the left anterior descending coronary artery. A...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2020-04, Vol.27 (2), p.519-531
Main Authors: Xi, Xiao-Ying, Zhang, Feifei, Wang, Jianfeng, Gao, Wei, Tian, Yi, Xu, Hongyu, Xu, Min, Wang, Yuetao, Yang, Min-Fu
Format: Article
Language:English
Subjects:
Cardiology
FDG
Heart attacks
Imaging
Inflammation
Medicine
Medicine & Public Health
Myocardial infarction
Nuclear Medicine
Original Article
PET
Physiology
Radiology
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Summary:The aim of the study was to investigate the relationship between post-myocardial infarction (MI) inflammation and left ventricular (LV) remodeling in a swine model by 18F-fluorodeoxyglucose (FDG) imaging. MI was induced in swine by balloon occlusion of the left anterior descending coronary artery. A series of FDG positron emission tomography (PET) images were taken within 2 weeks post-MI, employing a comprehensive strategy to suppress the physiological uptake of cardiomyocytes. Echocardiography was applied to evaluate LV volume, global and regional function. CD68+ macrophage and glucose transporters (GLUT-1, -3 and -4) were investigated by immunostaining. The physiological uptake of myocardium was adequately suppressed in 92.3% of PET scans verified by visual analysis, which was further confirmed by the minimal expression of myocardial GLUT-4. Higher FDG uptake was observed in the infarct than in the remote area and persisted within the observational period of 2 weeks. The FDG uptake of infarcted myocardium on day 1 post-MI was correlated with LV global remodeling, and the FDG uptake of infarcted myocardium on days 1 and 8 post-MI had a trend of correlating with regional remodeling of the infarct area. We here report a feasible swine model for investigating post-MI inflammation. FDG signal in the infarct area of swine persisted for a longer duration than has been reported in small animals. FDG activity in the infarct area could predict LV remodeling.
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-019-01952-0