Systematic review of biological therapy to accelerate orthodontic tooth movement in animals: Translational approach

• Published in: Archives of oral biology 2020-02, Vol.110, p.104597-104597, Article 104597
• Main Authors: Santana, Lucas Garcia, Duarte-Rodrigues, Lucas, Alves-Duarte, Ana Caroline, Galvão, Endi Lanza, Douglas-de-Oliveira, Dhelfeson Willya, Marques, Leandro Silva, Falci, Saulo Gabriel Moreira
• Format: Article
• Language: English
• Subjects: Animals; Biological Therapy; Dentistry; Disease Models, Animal; Orthodontic tooth movement; Proteomics; Systematic review; Tooth Movement Techniques
• ISSN: 0003-9969; 1879-1506
• DOI: 10.1016/j.archoralbio.2019.104597

•Review that tie together the experimental studies trying to move teeth faster.•Leading to a focused conclusion on the translational potential of these hypotheses.•51 included studies covered a wide range of substances, chemicals and genes.•The validity of the evidence is flawed to support the translation of these results.•Well-designed experimental studies are needed to elevate translation in this field. To systematically review and evaluate what is known regarding contemporary biological therapy capable of accelerating orthodontic tooth movement (OTM) in animal model. MedLine, Scopus, Web of Science and OpenGrey were searched without restrictions until June 2019. Following study retrieval and selection, relevant data was extracted using a standardized table. Risk of bias (RoB) assessment was performed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Fifty-one animal studies were included. Two biological therapies were identified as capable of accelerating the OTM: chemical methods (49 studies) and gene therapy (2 studies). The main substances that increased the OTM rate were cytokines (13 studies), followed by growth factors (6 studies) and hormones (5 studies). Most studies were assessed to be at unclear or high RoB. The application protocols, measurement and reporting of outcomes varied widely and methodologies were not adequately reported. Although biological therapies to accelerate OTM have been widely tested and effective in preclinical studies, the validity of the evidence is flawed to support translational of these results. There is a need for well-designed experimental studies to translate these methods for clinical field.