Placental fibronectin staining is unaffected in pregnancies complicated by late‐onset intrauterine growth restriction and small for gestational age fetuses

Objective To investigate the placental staining pattern of fibronectin, an extracellular matrix protein essential for trophoblastic invasion, in pre‐eclampsia and fetal growth restriction. Methods This was a retrospective study conducted at the University of Udine, including the placentas of women w...

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Bibliographic Details
Published in:International journal of gynecology and obstetrics 2020-02, Vol.148 (2), p.253-260
Main Authors: Fruscalzo, Arrigo, Londero, Ambrogio P., Orsaria, Maria, Marzinotto, Stefania, Driul, Lorenza, Di Loreto, Carla, Mariuzzi, Laura
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Extracellular matrix
Female
Fetal growth retardation
Fetal Growth Retardation - metabolism
Fibronectin
Fibronectins - metabolism
HELLP Syndrome - metabolism
Humans
Immunohistochemistry
Infant, Newborn
Infant, Small for Gestational Age - metabolism
Placenta
Placenta - metabolism
Pre-Eclampsia - metabolism
Pregnancy
Pre‐eclampsia
Retrospective Studies
Small for gestational age
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Summary:Objective To investigate the placental staining pattern of fibronectin, an extracellular matrix protein essential for trophoblastic invasion, in pre‐eclampsia and fetal growth restriction. Methods This was a retrospective study conducted at the University of Udine, including the placentas of women with pre‐eclampsia and fetal growth restriction collected between January 1, 2001, and December 31, 2010. Fibronectin was evaluated in placental tissue micro‐array by immunohistochemistry, describing localization and intensity of staining. Results The study included the placentas of 36 women with early‐onset (delivery
ISSN:0020-7292
1879-3479
DOI:10.1002/ijgo.13060