Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis

Recent data show that species are prevalent respiratory infections in children with cystic fibrosis (CF). The biological significance of these infections is unknown. We aimed to evaluate longitudinal associations between infections and lung disease in young children with CF. Longitudinal data on 330...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2020-03, Vol.201 (6), p.688-696
Main Authors: Breuer, Oded, Schultz, Andre, Garratt, Luke W, Turkovic, Lidija, Rosenow, Tim, Murray, Conor P, Karpievitch, Yuliya V, Akesson, Lauren, Dalton, Samuel, Sly, Peter D, Ranganathan, Sarath, Stick, Stephen M, Caudri, Daan
Format: Article
Language:English
Subjects:
Cystic fibrosis
Infections
Lung diseases
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Summary:Recent data show that species are prevalent respiratory infections in children with cystic fibrosis (CF). The biological significance of these infections is unknown. We aimed to evaluate longitudinal associations between infections and lung disease in young children with CF. Longitudinal data on 330 children participating in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis surveillance program between 2000 and 2018 who underwent annual chest computed tomography (CT) imaging and BAL were used to determine the association between infections and the progression of structural lung disease. Results were adjusted for the effects of other common infections, associated variables, and repeated visits. Secondary outcomes included inflammatory markers in BAL, respiratory symptoms, and admissions for exacerbations. , , , and infections were all associated with worse CT scores in the same year (  
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201908-1585OC