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Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis
Recent data show that species are prevalent respiratory infections in children with cystic fibrosis (CF). The biological significance of these infections is unknown. We aimed to evaluate longitudinal associations between infections and lung disease in young children with CF. Longitudinal data on 330...
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| Published in: | American journal of respiratory and critical care medicine 2020-03, Vol.201 (6), p.688-696 |
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| Main Authors: | , , , , , , , , , , , , |
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| container_end_page | 696 |
| container_issue | 6 |
| container_start_page | 688 |
| container_title | American journal of respiratory and critical care medicine |
| container_volume | 201 |
| creator | Breuer, Oded Schultz, Andre Garratt, Luke W Turkovic, Lidija Rosenow, Tim Murray, Conor P Karpievitch, Yuliya V Akesson, Lauren Dalton, Samuel Sly, Peter D Ranganathan, Sarath Stick, Stephen M Caudri, Daan |
| description | Recent data show that
species are prevalent respiratory infections in children with cystic fibrosis (CF). The biological significance of these infections is unknown.
We aimed to evaluate longitudinal associations between
infections and lung disease in young children with CF.
Longitudinal data on 330 children participating in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis surveillance program between 2000 and 2018 who underwent annual chest computed tomography (CT) imaging and BAL were used to determine the association between
infections and the progression of structural lung disease. Results were adjusted for the effects of other common infections, associated variables, and repeated visits. Secondary outcomes included inflammatory markers in BAL, respiratory symptoms, and admissions for exacerbations.
,
,
, and
infections were all associated with worse CT scores in the same year (
|
| doi_str_mv | 10.1164/rccm.201908-1585OC |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2316779866</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2316779866</sourcerecordid><originalsourceid>FETCH-LOGICAL-c331t-29802d674e3e21044387ba9d050cfdb971314345fe4f19308bcfdeebc43412663</originalsourceid><addsrcrecordid>eNpdUU1LxTAQDKL48fQPeJCAFy_VbJI2zVHqJzxQUMFbadPtM9LXPrMt4r83-tSDp12GmWF3hrFDEKcAmT4Lzi1PpQAr8gTSPL0rNtgupCpNtDViM-7CqERr-7zD9ohehQCZg9hmOwqMNkrYXVaf0wrDwnfdRPy2b9GNfuiJV33D78OwCEgUAT60_GEMkxunUHV8PvULfuEJK0Lue168-K4J2PN3P77w4oNG7_iVr8NAnvbZVlt1hAc_c8aeri4fi5tkfnd9W5zPE6cUjIm0uZBNZjQqlCC0VrmpK9uIVLi2qa0BBVrptEXdglUiryOMWLsIgswyNWMna99VGN4mpLFcenLYdVWPw0SlVJAZY_Nv6vE_6uswhT5eF1l5DMbImOOMyTXLxT8oYFuugl9W4aMEUX41UH41UK4bKNcNRNHRj_VUL7H5k_xGrj4BQ6OCIQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2383097215</pqid></control><display><type>article</type><title>Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis</title><source>Freely Accessible Journals</source><source>EZB Electronic Journals Library</source><creator>Breuer, Oded ; Schultz, Andre ; Garratt, Luke W ; Turkovic, Lidija ; Rosenow, Tim ; Murray, Conor P ; Karpievitch, Yuliya V ; Akesson, Lauren ; Dalton, Samuel ; Sly, Peter D ; Ranganathan, Sarath ; Stick, Stephen M ; Caudri, Daan</creator><creatorcontrib>Breuer, Oded ; Schultz, Andre ; Garratt, Luke W ; Turkovic, Lidija ; Rosenow, Tim ; Murray, Conor P ; Karpievitch, Yuliya V ; Akesson, Lauren ; Dalton, Samuel ; Sly, Peter D ; Ranganathan, Sarath ; Stick, Stephen M ; Caudri, Daan</creatorcontrib><description>Recent data show that
species are prevalent respiratory infections in children with cystic fibrosis (CF). The biological significance of these infections is unknown.
We aimed to evaluate longitudinal associations between
infections and lung disease in young children with CF.
Longitudinal data on 330 children participating in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis surveillance program between 2000 and 2018 who underwent annual chest computed tomography (CT) imaging and BAL were used to determine the association between
infections and the progression of structural lung disease. Results were adjusted for the effects of other common infections, associated variables, and repeated visits. Secondary outcomes included inflammatory markers in BAL, respiratory symptoms, and admissions for exacerbations.
,
,
, and
infections were all associated with worse CT scores in the same year (
< 0.05). Only
and
were associated with progression in CT scores in the year after an infection and worse CT scores at the end of the observation period.
was most significantly associated with development of bronchiectasis (difference, 0.9; 95% confidence interval, 0.3-1.6;
= 0.003) and
with trapped air (difference, 3.2; 95% confidence interval, 1.0-5.4;
= 0.004).
infections were also associated with markers of neutrophilic inflammation (
< 0.001) and respiratory admissions risk (
= 0.008).
Lower respiratory
infections are associated with the progression of structural lung disease in young children with CF. This study highlights the need to further evaluate early
species infections and the feasibility, risk, and benefit of eradication regimens.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.201908-1585OC</identifier><identifier>PMID: 31747309</identifier><language>eng</language><publisher>United States: American Thoracic Society</publisher><subject>Cystic fibrosis ; Infections ; Lung diseases</subject><ispartof>American journal of respiratory and critical care medicine, 2020-03, Vol.201 (6), p.688-696</ispartof><rights>Copyright American Thoracic Society Mar 15, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-29802d674e3e21044387ba9d050cfdb971314345fe4f19308bcfdeebc43412663</citedby><cites>FETCH-LOGICAL-c331t-29802d674e3e21044387ba9d050cfdb971314345fe4f19308bcfdeebc43412663</cites><orcidid>0000-0002-4775-9095</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31747309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Breuer, Oded</creatorcontrib><creatorcontrib>Schultz, Andre</creatorcontrib><creatorcontrib>Garratt, Luke W</creatorcontrib><creatorcontrib>Turkovic, Lidija</creatorcontrib><creatorcontrib>Rosenow, Tim</creatorcontrib><creatorcontrib>Murray, Conor P</creatorcontrib><creatorcontrib>Karpievitch, Yuliya V</creatorcontrib><creatorcontrib>Akesson, Lauren</creatorcontrib><creatorcontrib>Dalton, Samuel</creatorcontrib><creatorcontrib>Sly, Peter D</creatorcontrib><creatorcontrib>Ranganathan, Sarath</creatorcontrib><creatorcontrib>Stick, Stephen M</creatorcontrib><creatorcontrib>Caudri, Daan</creatorcontrib><title>Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Recent data show that
species are prevalent respiratory infections in children with cystic fibrosis (CF). The biological significance of these infections is unknown.
We aimed to evaluate longitudinal associations between
infections and lung disease in young children with CF.
Longitudinal data on 330 children participating in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis surveillance program between 2000 and 2018 who underwent annual chest computed tomography (CT) imaging and BAL were used to determine the association between
infections and the progression of structural lung disease. Results were adjusted for the effects of other common infections, associated variables, and repeated visits. Secondary outcomes included inflammatory markers in BAL, respiratory symptoms, and admissions for exacerbations.
,
,
, and
infections were all associated with worse CT scores in the same year (
< 0.05). Only
and
were associated with progression in CT scores in the year after an infection and worse CT scores at the end of the observation period.
was most significantly associated with development of bronchiectasis (difference, 0.9; 95% confidence interval, 0.3-1.6;
= 0.003) and
with trapped air (difference, 3.2; 95% confidence interval, 1.0-5.4;
= 0.004).
infections were also associated with markers of neutrophilic inflammation (
< 0.001) and respiratory admissions risk (
= 0.008).
Lower respiratory
infections are associated with the progression of structural lung disease in young children with CF. This study highlights the need to further evaluate early
species infections and the feasibility, risk, and benefit of eradication regimens.</description><subject>Cystic fibrosis</subject><subject>Infections</subject><subject>Lung diseases</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdUU1LxTAQDKL48fQPeJCAFy_VbJI2zVHqJzxQUMFbadPtM9LXPrMt4r83-tSDp12GmWF3hrFDEKcAmT4Lzi1PpQAr8gTSPL0rNtgupCpNtDViM-7CqERr-7zD9ohehQCZg9hmOwqMNkrYXVaf0wrDwnfdRPy2b9GNfuiJV33D78OwCEgUAT60_GEMkxunUHV8PvULfuEJK0Lue168-K4J2PN3P77w4oNG7_iVr8NAnvbZVlt1hAc_c8aeri4fi5tkfnd9W5zPE6cUjIm0uZBNZjQqlCC0VrmpK9uIVLi2qa0BBVrptEXdglUiryOMWLsIgswyNWMna99VGN4mpLFcenLYdVWPw0SlVJAZY_Nv6vE_6uswhT5eF1l5DMbImOOMyTXLxT8oYFuugl9W4aMEUX41UH41UK4bKNcNRNHRj_VUL7H5k_xGrj4BQ6OCIQ</recordid><startdate>20200315</startdate><enddate>20200315</enddate><creator>Breuer, Oded</creator><creator>Schultz, Andre</creator><creator>Garratt, Luke W</creator><creator>Turkovic, Lidija</creator><creator>Rosenow, Tim</creator><creator>Murray, Conor P</creator><creator>Karpievitch, Yuliya V</creator><creator>Akesson, Lauren</creator><creator>Dalton, Samuel</creator><creator>Sly, Peter D</creator><creator>Ranganathan, Sarath</creator><creator>Stick, Stephen M</creator><creator>Caudri, Daan</creator><general>American Thoracic Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4775-9095</orcidid></search><sort><creationdate>20200315</creationdate><title>Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis</title><author>Breuer, Oded ; Schultz, Andre ; Garratt, Luke W ; Turkovic, Lidija ; Rosenow, Tim ; Murray, Conor P ; Karpievitch, Yuliya V ; Akesson, Lauren ; Dalton, Samuel ; Sly, Peter D ; Ranganathan, Sarath ; Stick, Stephen M ; Caudri, Daan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-29802d674e3e21044387ba9d050cfdb971314345fe4f19308bcfdeebc43412663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cystic fibrosis</topic><topic>Infections</topic><topic>Lung diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Breuer, Oded</creatorcontrib><creatorcontrib>Schultz, Andre</creatorcontrib><creatorcontrib>Garratt, Luke W</creatorcontrib><creatorcontrib>Turkovic, Lidija</creatorcontrib><creatorcontrib>Rosenow, Tim</creatorcontrib><creatorcontrib>Murray, Conor P</creatorcontrib><creatorcontrib>Karpievitch, Yuliya V</creatorcontrib><creatorcontrib>Akesson, Lauren</creatorcontrib><creatorcontrib>Dalton, Samuel</creatorcontrib><creatorcontrib>Sly, Peter D</creatorcontrib><creatorcontrib>Ranganathan, Sarath</creatorcontrib><creatorcontrib>Stick, Stephen M</creatorcontrib><creatorcontrib>Caudri, Daan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Breuer, Oded</au><au>Schultz, Andre</au><au>Garratt, Luke W</au><au>Turkovic, Lidija</au><au>Rosenow, Tim</au><au>Murray, Conor P</au><au>Karpievitch, Yuliya V</au><au>Akesson, Lauren</au><au>Dalton, Samuel</au><au>Sly, Peter D</au><au>Ranganathan, Sarath</au><au>Stick, Stephen M</au><au>Caudri, Daan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2020-03-15</date><risdate>2020</risdate><volume>201</volume><issue>6</issue><spage>688</spage><epage>696</epage><pages>688-696</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Recent data show that
species are prevalent respiratory infections in children with cystic fibrosis (CF). The biological significance of these infections is unknown.
We aimed to evaluate longitudinal associations between
infections and lung disease in young children with CF.
Longitudinal data on 330 children participating in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis surveillance program between 2000 and 2018 who underwent annual chest computed tomography (CT) imaging and BAL were used to determine the association between
infections and the progression of structural lung disease. Results were adjusted for the effects of other common infections, associated variables, and repeated visits. Secondary outcomes included inflammatory markers in BAL, respiratory symptoms, and admissions for exacerbations.
,
,
, and
infections were all associated with worse CT scores in the same year (
< 0.05). Only
and
were associated with progression in CT scores in the year after an infection and worse CT scores at the end of the observation period.
was most significantly associated with development of bronchiectasis (difference, 0.9; 95% confidence interval, 0.3-1.6;
= 0.003) and
with trapped air (difference, 3.2; 95% confidence interval, 1.0-5.4;
= 0.004).
infections were also associated with markers of neutrophilic inflammation (
< 0.001) and respiratory admissions risk (
= 0.008).
Lower respiratory
infections are associated with the progression of structural lung disease in young children with CF. This study highlights the need to further evaluate early
species infections and the feasibility, risk, and benefit of eradication regimens.</abstract><cop>United States</cop><pub>American Thoracic Society</pub><pmid>31747309</pmid><doi>10.1164/rccm.201908-1585OC</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4775-9095</orcidid></addata></record> |
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| language | eng |
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| source | Freely Accessible Journals; EZB Electronic Journals Library |
| subjects | Cystic fibrosis Infections Lung diseases |
| title | Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis |
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