Phenotypes and concentration of PON1 in cardiovascular disease: The role of nutrient intake

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2020-01, Vol.30 (1), p.40-48
• Main Authors: Ponce-Ruiz, Néstor, Murillo-González, Fátima E., Rojas-García, Aurora E., Bernal Hernández, Yael Y., Mackness, Mike, Ponce-Gallegos, Jaime, Barrón-Vivanco, Briscia S., Hernández-Ochoa, Isabel, González-Arias, Cyndia A., Ortega Cervantes, Laura, Cardoso-Saldaña, Guillermo, Medina-Díaz, Irma M.
• Format: Article
• Language: English
• Subjects: Cardiovascular diseases; Diet; Paraoxonase 1; PON1 concentration
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2019.08.013

Paraoxonase 1 (PON1) is considered to play a crucial role as an anti-atherosclerotic factor. The PON1 activity is affected by genetic polymorphisms, environmental factors, age, sex, lifestyle, pharmaceutical drugs, and dietary factors. The aim of this study was to evaluate the association between macro- and micronutrients as well as PON1 concentration and activities in patients with cardiovascular diseases (CVD), cardiovascular risk factors but no CVD (CRF), and in healthy controls (control group). A case-control study was carried out with 356 volunteers from the Mexican Institute of Social Security, Mexico. Clinical parameters, lipid profile, PON1 activities (AREase, LACase, CMPAase and PONase), and PON1 concentration were evaluated. There was a differential intake of macro- and micronutrients among the study groups. The intake of proteins and carbohydrates was higher in the CVD group than in the CFR and control groups (p