The Coexistence of Gliosarcoma and Arteriovenous Malformation with the BRAF V600E Mutation

BACKGROUNDThe authors report a case of a woman aged 33 years who suffered from the combination of primary gliosarcoma and arteriovenous malformation as the first clinical presentation of intracranial hemorrhage. CASE DESCRIPTIONSubsequently, gene examination rarely finds BRAF V600E mutation in the s...

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Bibliographic Details
Published in:World neurosurgery 2020, Vol.134, p.594-597
Main Authors: Zeng, Xi, Zhan, Qi, Gao, Yuan, Cui, Naihao, Dong, Minghao, Feng, Luqian, Chu, Liangzhao, Liu, Jian
Format: Report
Language:English
Online Access:Get full text
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Summary:BACKGROUNDThe authors report a case of a woman aged 33 years who suffered from the combination of primary gliosarcoma and arteriovenous malformation as the first clinical presentation of intracranial hemorrhage. CASE DESCRIPTIONSubsequently, gene examination rarely finds BRAF V600E mutation in the surgical specimen. The lesion was not completely identified with magnetic resonance imaging and digital subtraction angiography. CONCLUSIONSThis case illustrates the occult and unusual feature of gliosarcoma. The pathogenesis of such coexistence might be related to underlying genetic alterations.
ISSN:1878-8769
DOI:10.1016/j.wneu.2019.11.079