Predictive value of serum β-human chorionic gonadotropin for early pregnancy outcomes

Purpose To evaluate the relationship between serum β-human chorionic gonadotropin (HCG) levels and early pregnancy outcomes in women who became pregnant using assisted reproductive technologies (ARTs). Methods In this study, we retrospectively analyzed 523 pregnancies after ART use, with respect to...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2020, Vol.301 (1), p.295-302
Main Authors: Wang, Zengyan, Gao, Yong, Zhang, Dan, Li, Yubin, Luo, Lu, Xu, Yanwen
Format: Article
Language:English
Subjects:
Drug dosages
Embryos
Endocrinology
Gynecologic Endocrinology and Reproductive Medicine
Gynecology
Human Genetics
Medicine
Medicine & Public Health
Obstetrics
Obstetrics/Perinatology/Midwifery
Pregnancy complications
Reproductive health
Statistical analysis
Ultrasonic imaging
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Summary:Purpose To evaluate the relationship between serum β-human chorionic gonadotropin (HCG) levels and early pregnancy outcomes in women who became pregnant using assisted reproductive technologies (ARTs). Methods In this study, we retrospectively analyzed 523 pregnancies after ART use, with respect to the early clinical outcomes based on the serum β-HCG levels. The significance of using serum β-HCG levels to predict outcomes in early pregnancy was evaluated by the receiver operating characteristic (ROC) curve and cutoff values of serum β-HCG. Results We found that elevated serum β-HCG levels resulted in decreased biochemical pregnancy rates, increased multiple rates, and decreased ongoing and ectopic pregnancy rates. The cutoff values of serum β-HCG levels for the prediction of biochemical pregnancy were 213.15 IU/L, 986.65 IU/L, and 2206.5 IU/L for singletons, multiples, and twins or triplets, respectively. Conclusion The serum β-HCG level 14 or 12 days after D3 or D5 embryo transfer (conducted 3 or 5 days after oocyte retrieval), respectively, predicts biochemical/clinical pregnancy and singleton/multiple pregnancy with robust sensitivity and specificity.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-019-05388-2