Hypocholesterolemic Effect of Potential Probiotic Lactobacillus fermentum Strains Isolated from Traditional Fermented Foods in Wistar Rats

The current research project was undertaken to explore the therapeutic potential of two potent probiotic Lactobacillus fermentum strains, i.e., PD2 and PH5 in a hyperlipemic healthy adult Wistar rat model, with a particular focus as biotherapeutics for the management of high cholesterol in Indian po...

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Bibliographic Details
Published in:Probiotics and antimicrobial proteins 2020-09, Vol.12 (3), p.1002-1011
Main Authors: Thakkar, Pooja N., Patel, Ami, Modi, Hasmukh A., Prajapati, Jashbhai B.
Format: Article
Language:English
Subjects:
Animal models
Applied Microbiology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cholesterol
Dietary supplements
Fecal coliforms
Fermented food
High cholesterol diet
Lactobacillus fermentum
Liver
Low density lipoprotein
Microbiology
Nutrition
Probiotics
Protein Science
Rodents
Triglycerides
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Summary:The current research project was undertaken to explore the therapeutic potential of two potent probiotic Lactobacillus fermentum strains, i.e., PD2 and PH5 in a hyperlipemic healthy adult Wistar rat model, with a particular focus as biotherapeutics for the management of high cholesterol in Indian population. Rats fed on cholesterol-enriched diet supplemented with potential probiotics strain Lactobacillus fermentum PH5 significantly affected serum lipid profile by reducing serum cholesterol (67.21%), triglycerides level (66.21%), and LDL cholesterol level (63.25%) in comparison to rats that received cholesterol-enriched diet (Model) only. Both the strains decreased the cholesterol levels in liver compared with Model group, but PH5 was found to be more effective (30.65% reduction) in liver total cholesterol (TC) lowering action. In addition, the fecal coliforms were significantly reduced besides increased LAB in feces of rats receiving probiotic curd having Lactobacillus fermentum PH5. Our results demonstrated that supplementation with either of the two strains was efficient in reducing serum cholesterol, LDL-cholesterol and TG concentrations in rats compared to those fed the same high-cholesterol diet but without LAB supplementation.
ISSN:1867-1306
1867-1314
DOI:10.1007/s12602-019-09622-w