One-carbon metabolism for cancer diagnostic and therapeutic approaches

Altered metabolism is critical for the rapid and unregulated proliferation of cancer cells; hence the requirement for an abundant source of nucleotides. One characteristic of this metabolic reprogramming is in one-carbon (1C) metabolism, which is particularly noteworthy for its role in DNA synthesis...

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Bibliographic Details
Published in:Cancer letters 2020-02, Vol.470, p.141-148
Main Authors: Asai, Ayumu, Konno, Masamitsu, Koseki, Jun, Taniguchi, Masateru, Vecchione, Andrea, Ishii, Hideshi
Format: Article
Language:English
Subjects:
Anticancer drugs
Antineoplastic drugs
Antitumor agents
Cancer
Cell growth
Cell proliferation
Cell survival
DNA biosynthesis
DNA methylation
DNA synthesis
Folate
Kinases
Malignancy
Medical diagnosis
Metabolism
Metabolites
Methionine
Methylation
Nucleotides
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Summary:Altered metabolism is critical for the rapid and unregulated proliferation of cancer cells; hence the requirement for an abundant source of nucleotides. One characteristic of this metabolic reprogramming is in one-carbon (1C) metabolism, which is particularly noteworthy for its role in DNA synthesis. Various forms of methylation are also noteworthy as they relate to cancer cell survival and proliferation. In recent years, 1C metabolism has received substantial attention for its role in cancer malignancy via these functions. Therefore, therapeutic inhibitors targeting 1C metabolism have been utilized as anticancer drugs. This review outlines the importance of 1C metabolism and its clinical application in cancer. Understanding 1C metabolism could aid the development of novel cancer diagnostic and therapeutic methods. •One-carbon metabolism has attracted particular attention in recent cancer research.•Anticancer drugs targeting mitochondrial one-carbon metabolism have been developed.•One-carbon metabolism is involved in the malignancy through methylation reactions on various substances.•One-carbon metabolism is applicable to cancer diagnosis and cancer therapy.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2019.11.023