Effect of VNTR Polymorphism of the AS3MT Gene and Obstetrical Complications on the Severity of Schizophrenia

The role of the VNTR polymorphism of the AS3MT gene in determining the clinical features of schizophrenia and schizophrenic spectrum disorders was studied. The analysis included 670 individuals. We found no differences in PANSS scores for positive, negative, and common psychopathological symptoms be...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-11, Vol.168 (1), p.84-86
Main Authors: Korovaitseva, G. I., Gabaeva, M. V., Yunilainen, O. A., Golimbet, V. E.
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
Cell Biology
Emotional behavior
Environmental factors
Female
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Genotype
Genotype-environment interactions
Humans
Internal Medicine
Laboratory Medicine
Male
Medical research
Medicine, Experimental
Mental disorders
Methyltransferases - genetics
Minisatellite Repeats - genetics
Pathology
Polymorphism
Polymorphism, Genetic - genetics
Pregnancy
Pregnancy Complications - genetics
Schizophrenia
Schizophrenia - genetics
Schizophrenia - pathology
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Summary:The role of the VNTR polymorphism of the AS3MT gene in determining the clinical features of schizophrenia and schizophrenic spectrum disorders was studied. The analysis included 670 individuals. We found no differences in PANSS scores for positive, negative, and common psychopathological symptoms between the carriers of different genotypes. The interaction of the studied polymorphism and obstetrical complications as an environmental factor was found. The genotype-environment interactions were identified for one of the characteristics reflecting the severity of schizophrenia: the level of negative symptoms. Women with the V2/V2 genotype, who have obstetrical complications, showed significantly higher negative symptoms scores, which was associated with a poor prognosis of the disease.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04653-3