A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat

Wearable sweat sensors have the potential to provide continuous measurements of useful biomarkers. However, current sensors cannot accurately detect low analyte concentrations, lack multimodal sensing or are difficult to fabricate at large scale. We report an entirely laser-engraved sensor for simul...

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Bibliographic Details
Published in:Nature biotechnology 2020-02, Vol.38 (2), p.217-224
Main Authors: Yang, Yiran, Song, Yu, Bo, Xiangjie, Min, Jihong, Pak, On Shun, Zhu, Lailai, Wang, Minqiang, Tu, Jiaobing, Kogan, Adam, Zhang, Haixia, Hsiai, Tzung K., Li, Zhaoping, Gao, Wei
Format: Article
Language:English
Subjects:
639/166/985
639/301/1005
639/301/930
Adolescent
Adult
Aged
Agriculture
Bioinformatics
Biomarkers
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Chemical perception
Chemoreception
Engraving
Equipment Design
Gout
Gout - diagnosis
Humans
Lasers
Levels
Life Sciences
Low concentrations
Metabolic disorders
Microfluidics
Middle Aged
Monitoring
Organic chemistry
Phenols
Reproducibility of Results
Rheumatism
Sensors
Skin
Sweat
Sweat - chemistry
Temperature
Tyrosine
Tyrosine - analysis
Tyrosine - chemistry
Uric acid
Uric Acid - analysis
Uric Acid - chemistry
Vital Signs
Wearable Electronic Devices
Wearable technology
Young Adult
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Summary:Wearable sweat sensors have the potential to provide continuous measurements of useful biomarkers. However, current sensors cannot accurately detect low analyte concentrations, lack multimodal sensing or are difficult to fabricate at large scale. We report an entirely laser-engraved sensor for simultaneous sweat sampling, chemical sensing and vital-sign monitoring. We demonstrate continuous detection of temperature, respiration rate and low concentrations of uric acid and tyrosine, analytes associated with diseases such as gout and metabolic disorders. We test the performance of the device in both physically trained and untrained subjects under exercise and after a protein-rich diet. We also evaluate its utility for gout monitoring in patients and healthy controls through a purine-rich meal challenge. Levels of uric acid in sweat were higher in patients with gout than in healthy individuals, and a similar trend was observed in serum. Low levels of uric acid and tyrosine in sweat are detected in patients with gout and healthy individuals with an entirely laser-engraved wearable sensor.
ISSN:1087-0156
1546-1696
DOI:10.1038/s41587-019-0321-x