Cytokine Profile in Experimental Models of Critical Limb Ischemia in Rats

We studied the effect of intramuscular administration of a cellular product (mesenchymal stem cells, conditioned media, and erythropoietin) on cytokine levels in blood serum, conditioned media of bone marrow mononuclears, and calf muscles in Wistar rats with hind limb ischemia. It is shown that the...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-11, Vol.168 (1), p.150-155
Main Authors: Lykov, A. P., Bondarenko, N. A., Poveshchenko, O. V., Kabakov, A. V., Surovtseva, M. A., Kim, I. I., Kazakov, O. V., Poveshchenko, A. F., Yankaite, E. V.
Format: Article
Language:English
Subjects:
Animals
Biological products
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cell Biology
Cytokines
Cytokines - blood
Erythropoietin
Erythropoietin - blood
Hindlimb - pathology
Inflammation
Internal Medicine
Ischemia
Ischemia - blood
Ischemia - pathology
Laboratory Medicine
Male
Mesenchyme
Muscles
Pathology
Rats
Rats, Wistar
Rodents
Stem cell transplantation
Stem cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the effect of intramuscular administration of a cellular product (mesenchymal stem cells, conditioned media, and erythropoietin) on cytokine levels in blood serum, conditioned media of bone marrow mononuclears, and calf muscles in Wistar rats with hind limb ischemia. It is shown that the cellular product reduces the proinflammatory background at the early stages of the experiment and increases the content proangiogenic factors.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04666-y