Tobacco smoking is an independent factor associated with retinal damage in systemic lupus erythematosus: a cross-sectional and retrospective study

• Published in: Rheumatology international 2020-03, Vol.40 (3), p.367-374
• Main Authors: Rúa-Figueroa, Iñigo, Erausquin, Celia, Rua-Figueroa, Celia, González-Martín, Jesús, Naranjo, Antonio, Ojeda, Soledad, Francisco, Félix, Quevedo, Juan C., Cáceres, Laura, López, Ruben, Greco, Martin, Altabás-González, Irene, Pérez, Yanira, Rubiño, Francisco, Rodríguez-Lozano, Carlos
• Format: Article
• Language: English
• Subjects: Adult; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Lupus; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - pathology; Male; Medicine; Medicine & Public Health; Middle Aged; Observational Research; Retina - pathology; Retinal Diseases - etiology; Retinal Diseases - pathology; Retrospective Studies; Rheumatology; Risk Factors; Smoking; Tobacco; Tobacco Smoking - adverse effects
• ISSN: 0172-8172; 1437-160X
• DOI: 10.1007/s00296-019-04473-8

To analyze the influence of tobacco smoking on systemic lupus erythematosus (SLE) clinical features and damage. Cross-sectional and retrospective, case–control study comparing SLE patients with and without tobacco exposure. Cumulative clinical data and comorbidities were collected, and severity (Katz index) and damage (SLICC/ACR damage index) (SDI) indices were calculated. Pack-years (PY) was used to estimate lifetime tobacco exposure. A logistic regression was carried out to explore the impact of tobacco use on retinal damage. 216 patients were included. The mean age was 49 years (± 12.7), 93% were females, and median disease duration was 17 years [interquartile range (IQR):9–25]. Fifty-three percent of patients were smokers at some point. The median PY was 13 (IQR: 6–20.5). Only 54.8% of active smokers recalled having been informed of the negative effects of smoking, versus 83.3% of never smokers ( 0 ( p  = 0.002) and retinal damage ( p  = 0.02). In a multivariate analysis exploring factors associated with retinal damage, any previous smoking history and SDI remained associated with retinal damage. Tobacco smoking is associated with cutaneous manifestations and damage and is an independent predictor of retinal damage in SLE patients.