Ventricular conduction delay as marker of risk in Brugada Syndrome. Results from the analysis of clinical and electrocardiographic features of a large cohort of patients

Brugada Syndrome is a genetic arrhythmogenic disease with a variable clinical spectrum. The role of clinical and ECG parameters in the risk stratification is still uncertain. In a large cohort of Brugada patients we analysed clinical and ECG features to determine the variables with prognostic value...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cardiology 2020-03, Vol.302, p.171-177
Main Authors: Giustetto, Carla, Nangeroni, Giulia, Cerrato, Natascia, Rudic, Boris, Tülümen, Erol, Gribaudo, Elena, Giachino, Daniela Francesca, Barbonaglia, Lorella, Biava, Lorenza Michela, Carvalho, Paula, Bergamasco, Laura, Borggrefe, Martin, Gaita, Fiorenzo
Format: Article
Language:English
Subjects:
Adult
Brugada Syndrome
Brugada Syndrome - complications
Brugada Syndrome - physiopathology
Brugada Syndrome - therapy
Conduction delay
Death, Sudden, Cardiac - epidemiology
Death, Sudden, Cardiac - etiology
Defibrillators, Implantable
Electrocardiography
Female
Follow-Up Studies
Heart Rate - physiology
Humans
Incidence
Italy - epidemiology
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Assessment - methods
Risk Factors
Sudden cardiac death
Survival Rate - trends
Unexplained syncope
Ventricular Fibrillation - epidemiology
Ventricular Fibrillation - etiology
Ventricular Fibrillation - therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Brugada Syndrome is a genetic arrhythmogenic disease with a variable clinical spectrum. The role of clinical and ECG parameters in the risk stratification is still uncertain. In a large cohort of Brugada patients we analysed clinical and ECG features to determine the variables with prognostic value for the occurrence of a first documented arrhythmic event and for recurrences. We enrolled 614 patients, subdivided into 3 groups according to their clinical presentation: 531 (88%) asymptomatic, 69 (10%) with previous unexplained syncope and 14 (2%) with aborted sudden death. We also compared the ECG characteristics of patients with a single documented arrhythmic event (either at presentation or at follow-up, 17 patients), with those of patients with arrhythmic recurrences (13 patients). The event rate was 1.3% in the asymptomatic patients and 15% among patients with unexplained syncope (median follow-up 6 years), p 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2019.11.121