Cytotoxic and anti-inflammatory activities of secondary metabolites from Ophiorrhiza baviensis growing in Thua Thien Hue, Vietnam

A new ursane-type triterpene, 3β,23,24-trihydroxyurs-12-en-28-oic acid (1), together with eight known compounds (2-9) were isolated from the aerial parts of Ophiorrhiza baviensis. Among them, compounds 2-5 were found for the first time from the genus Ophiorrhiza, while compounds 6-9 were reported fr...

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Bibliographic Details
Published in:Natural product research 2021-11, Vol.35 (22), p.4218-4224
Main Authors: Viet Cuong, Le Canh, Anh, Le Tuan, Huu Dat, Ton That, Anh, Tran Thi Phuong, Lien, Le Quynh, Kim, Young Ho, Tuan Anh, Hoang Le
Format: Article
Language:English
Subjects:
anti-inflammatory activity
cytotoxic activity
Ophiorrhiza baviensis
triterpene
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Summary:A new ursane-type triterpene, 3β,23,24-trihydroxyurs-12-en-28-oic acid (1), together with eight known compounds (2-9) were isolated from the aerial parts of Ophiorrhiza baviensis. Among them, compounds 2-5 were found for the first time from the genus Ophiorrhiza, while compounds 6-9 were reported from O. baviensis for the first time. Their structures were elucidated by analysis of HR-ESI-MS and NMR ( 1 H-NMR, 13 C-NMR, HSQC, and HMBC) spectra, as well as comparison with those reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against MCF-7, Hela, KB, A549, and SK-LU-1 cancer cell lines and their effects on LPS-induced NO production in RAW264.7 cells. This is the first report of chemical constituents and biological activities of O. baviensis.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1693564