On the winter enhancement of adaptive humoral immunity: hypothesis testing in desert hamsters (Phodopus roborovskii: Cricetidae, Rodentia) kept under long‐day and short‐day photoperiod

• Published in: Integrative zoology 2020-05, Vol.15 (3), p.232-247
• Main Authors: VASILIEVA, Nina Yu, KHRUSHCHOVA, Anastasiya M., KUPTSOV, Alexander V., SHEKAROVA, Olga N., SOKOLOVA, Olga V., WANG, Dehua, ROGOVIN, Konstantin A.
• Format: Article
• Language: English
• Subjects: adaptive humoral immunity; Blood cells; Cortisol; desert hamster; Deserts; Erythrocytes; Freshwater mammals; Generalized linear models; Hormones; Humoral immunity; Hypotheses; Immune response; Immunity; Leukocytes (granulocytic); Lymphocytes; Males; Mass; Metabolic rate; Metabolism; Phodopus roborovskii; photoperiodicity; Photoperiods; Reproductive effort; Reproductive system; Sheep; Winter; winter immunoenhancement
• ISSN: 1749-4877; 1749-4869; 1749-4877
• DOI: 10.1111/1749-4877.12419

We tested the winter immunity enhancement hypothesis (WIEH) on male desert hamsters (Phodopus roborovskii) kept under long‐day (LD) and short‐day (SD) photoperiods. We assumed that under SD in a laboratory, the adaptive humoral immune responsiveness to the antigenic challenge would be enhanced due to the lack of winter physical stressors and food shortages and/or because of the action of an endogenous winter bolstering mechanism, while under LD the immune responsiveness would be suppressed by the activity of the reproductive system. The results support the WIEH in part. We did not find a difference in antibody production in response to sheep erythrocytes between SD and LD hamsters, but SD males had the lower number of granulocytes and the higher number of lymphocytes in white blood cell counts. Reproductive activity was lower in SD males. These males demonstrated an increase in their mass‐specific resting metabolic rate, their mass‐specific maximal metabolic rate and their level of cortisol. The result of a generalized linear model analysis indicates the negative effect on secondary immunoresponsiveness to sheep erythrocytes of mid‐ventral gland size, the organ characterizing individual reproductive quality, and designates a tradeoff between antibody production and reproductive effort. The mass‐independent maximal metabolic rate also negatively affected antibody production, indicating a tradeoff between maximal aerobic performance and the adaptive immune function. The higher stress in SD males seems to be the most likely reason for the lack of the effect of daylight duration on antibody production.