Sophorolipid biosynthesis and production from diverse hydrophilic and hydrophobic carbon substrates

Sophorolipids (SLs), mainly synthesized by yeasts, were a sort of biosurfactant with the highest fermentation level at present. In recent years, SLs have drawn extensive attention for their excellent physiochemical properties and physiological activities. Besides, issues such as economics, sustainab...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2020, Vol.104 (1), p.77-100
Main Authors: Ma, Xiaojing, Meng, Li, Zhang, Huimin, Zhou, Liye, Yue, Junyang, Zhu, Huixia, Yao, Risheng
Format: Article
Language:English
Subjects:
Agricultural economics
Agricultural wastes
Biomedical and Life Sciences
Biosurfactants
Biosynthesis
Biotechnology
Carbon
Carbon sources
Cultivation
Fermentation
Food industry
Genetic modification
Genetically modified organisms
Hydrophilicity
Hydrophobicity
Life Sciences
Microbial Genetics and Genomics
Microbiology
Microorganisms
Mini-Review
Organic chemistry
Petroleum refining
Physiochemistry
Production costs
Renewable resources
Substrates
Sustainable yield
Waste management
Waste streams
Yeasts
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Summary:Sophorolipids (SLs), mainly synthesized by yeasts, were a sort of biosurfactant with the highest fermentation level at present. In recent years, SLs have drawn extensive attention for their excellent physiochemical properties and physiological activities. Besides, issues such as economics, sustainability, and use of renewable resources also stimulate the shift from chemical surfactants towards green or microbial-derived biosurfactants. SLs’ large-scale production and application were restricted by the relatively high production costs. Currently, waste streams from agriculture, food and oil refining industries, etc., have been exploited as low-cost renewable substrates for SL production. Advanced cultivation method, uncommonly used substrates, and new genetically modified SL-producing mutants were also designed and applied to improve the productivity or the special properties of SLs. In this review, a systematic and detailed description of primary and secondary metabolism pathways involved in SL biosynthesis was summarized firstly. Furthermore, based on the pathways of SL biosynthesis from different carbon substrates, we reviewed the current knowledge and advances in the exploration of cost-effective and infrequently used hydrophilic and hydrophobic substrates for large or specialized SL production.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-019-10247-w