Effect of the levonorgestrel‐releasing intrauterine system on cardiovascular risk markers among women with thrombophilia or previous venous thromboembolism

Objective To assess the effects of the levonorgestrel‐releasing intrauterine system (LNG‐IUS) on standard cardiovascular risk markers among women with thrombophilia and/or previous venous thromboembolism (VTE). Methods A prospective cohort study enrolled women aged 18–45 years with thrombophilia and...

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Bibliographic Details
Published in:International journal of gynecology and obstetrics 2020-03, Vol.148 (3), p.381-385
Main Authors: Braga, Giordana C., Brito, Milena B., Ferriani, Rui A., Oliveira, Luciana C., Garcia, Andrea A., Pintão, Maria C., Vieira, Carolina S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brazil
Cardiovascular diagnostic techniques
Contraception
Contraceptive Agents, Female - adverse effects
Female
Humans
Intrauterine devices
Intrauterine Devices, Medicated - adverse effects
Levonorgestrel - adverse effects
Medicated intrauterine devices
Middle Aged
Prospective Studies
Risk Factors
Thrombophilia
Thrombophilia - complications
Thrombosis
Venous Thromboembolism - complications
Young Adult
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Summary:Objective To assess the effects of the levonorgestrel‐releasing intrauterine system (LNG‐IUS) on standard cardiovascular risk markers among women with thrombophilia and/or previous venous thromboembolism (VTE). Methods A prospective cohort study enrolled women aged 18–45 years with thrombophilia and/or a history of VTE who received the 52‐mg LNG‐IUS (20 μg/d initial release) at the University of Ribeirão Preto Medical School, Brazil, from January 2006 to December 2015. Before and 12 months after LNG‐IUS placement, the following cardiovascular risk markers were assessed: lipid profile, body mass index (BMI), blood glucose, systolic blood pressure, diastolic blood pressure, and waist circumference. The primary outcome was changes in cardiovascular risk markers. A subanalysis of anticoagulant users versus non‐users was also conducted. Results In total, 45 women were enrolled. BMI increased by 2.3% after 12 months of LNG‐IUS placement (P 
ISSN:0020-7292
1879-3479
DOI:10.1002/ijgo.13070