Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species: new genes/alleles, renaming recombinant entities and IPD-NHKIR updates

The Killer-cell Immunoglobulin-like Receptors (KIR) are encoded by a diverse group of genes, which are characterized by allelic polymorphism, gene duplications, and recombinations, which may generate recombinant entities. The number of reported macaque KIR sequences is steadily increasing, and these...

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Bibliographic Details
Published in:Immunogenetics (New York) 2020-02, Vol.72 (1-2), p.37-47
Main Authors: Bruijnesteijn, Jesse, de Groot, Natasja G., Otting, Nel, Maccari, Giuseppe, Guethlein, Lisbeth A., Robinson, James, Marsh, Steven G. E., Walter, Lutz, O’Connor, David H., Hammond, John A., Parham, Peter, Bontrop, Ronald E.
Format: Article
Language:English
Subjects:
"Nomenclature
Alleles
Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
databases and bioinformatics in Immunogenetics
Databases, Factual
Gene Function
Gene polymorphism
Gene sequencing
Genes
Human Genetics
Immunogenetics
Immunoglobulin-like receptors
Immunoglobulins
Immunology
Macaca mulatta - genetics
Monkeys & apes
Polymorphism
Polymorphism, Genetic
Receptors
Receptors, KIR - genetics
Receptors, KIR - immunology
Review
Species
Terminology as Topic
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Summary:The Killer-cell Immunoglobulin-like Receptors (KIR) are encoded by a diverse group of genes, which are characterized by allelic polymorphism, gene duplications, and recombinations, which may generate recombinant entities. The number of reported macaque KIR sequences is steadily increasing, and these data illustrate a gene system that may match or exceed the complexity of the human KIR cluster. This report lists the names of quality controlled and annotated KIR genes/alleles with all the relevant references for two different macaque species: rhesus and cynomolgus macaques. Numerous recombinant KIR genes in these species necessitate a revision of some of the earlier-published nomenclature guidelines. In addition, this report summarizes the latest information on the Immuno Polymorphism Database (IPD)-NHKIR Database, which contains annotated KIR sequences from four non-human primate species.
ISSN:0093-7711
1432-1211
DOI:10.1007/s00251-019-01135-8