Triterpenoids from the barks of Juglans hopeiensis

Nine undescribed triterpenoids (jughopenoids A-I), including seven nortriterpenoids and two normal triterpenoids, together with fourteen known analogues, were isolated from the barks of Juglans hopeiensis Hu. The structures of the undescribed triterpenoids were established by integrated spectroscopi...

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Published in:Phytochemistry (Oxford) 2020-02, Vol.170, p.112201-112201, Article 112201
Main Authors: Peng, Xiaogang, Lin, Yi, Liang, Jingjing, Zhou, Ming, Zhou, Jia, Ruan, Hanli
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Cell Proliferation - drug effects
Cell Survival - drug effects
Crystallography, X-Ray
Cytotoxicity
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Hep G2 Cells
HT29 Cells
Humans
Immunosuppression
Juglandaceae
Juglans - chemistry
Juglans hopeiensis Hu
Models, Molecular
Molecular Structure
PC-3 Cells
Phytochemicals - chemistry
Phytochemicals - isolation & purification
Phytochemicals - pharmacology
Plant Bark - chemistry
Structure-Activity Relationship
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
Triterpenoids
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Summary:Nine undescribed triterpenoids (jughopenoids A-I), including seven nortriterpenoids and two normal triterpenoids, together with fourteen known analogues, were isolated from the barks of Juglans hopeiensis Hu. The structures of the undescribed triterpenoids were established by integrated spectroscopic analysis and single crystal X-ray diffraction. Jughopenoid A represented an unprecedented lupane-type nortriterpenoid with a five-membered lactone ring A. Selected isolates were tested for their cytotoxic effects against human HT-29 colon carcinoma, human HepG2 hepatocellular carcinoma, and human PC-3 prostate cancer cell lines. Their immunosuppressive activities against ConA-induced T cell proliferation and LPS-induced B cell proliferation were also evaluated. [Display omitted] •Chemical constituents of the barks of Juglans hopeiensis were firstly investigated.•Nine previously undescribed and fourteen known triterpenoids were identified.•Jughopenoid A was a lupane-type nortriterpenoid with a five-membered lactone ring A.•Some isolates showed moderate immunosuppressive effects.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2019.112201