ALK-negative anaplastic large cell lymphoma with “Hodgkin-like” cytomorphology and nuclear expression of PAX5

Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity...

Full description

Saved in:
Bibliographic Details
Published in:Pathology, research and practice research and practice, 2020-02, Vol.216 (2), p.152724-152724, Article 152724
Main Authors: Fratoni, Stefano, Niscola, Pasquale, Zhao, Xiangfeng Frank, Larocca, Luigi Maria, Capalbo, Anna, Fabbretti, Maria, Bernardini, Laura, Abruzzese, Elisabetta
Format: Article
Language:English
Subjects:
Aged, 80 and over
ALK-negative anaplastic large cell lymphoma
Cell Nucleus - metabolism
Female
Humans
Lymph Nodes - metabolism
Lymph Nodes - pathology
Lymphoma, Large-Cell, Anaplastic - diagnosis
Lymphoma, Large-Cell, Anaplastic - metabolism
Lymphoma, Large-Cell, Anaplastic - pathology
PAX5
PAX5 Transcription Factor - genetics
PAX5 Transcription Factor - metabolism
“Hodgkin-like” features
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking “Hodgkin-like” cytomorphology and a very uncommon nuclear expression of PAX5.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2019.152724