Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial

•Acute radiation dermatitis (ARD) is the most frequently reported adverse effect of the breast radiotherapy.•This study aimed to investigate Nigella sativa L. (N. sativa) 5% gel effectiveness in preventing ARD in breast cancer patients.•The preventive use of the N. sativa gel significantly decreased...

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Bibliographic Details
Published in:Complementary therapies in medicine 2019-12, Vol.47, p.102205-102205, Article 102205
Main Authors: Rafati, Mohammadreza, Ghasemi, Arash, Saeedi, Majid, Habibi, Emran, Salehifar, Ebrahim, Mosazadeh, Mahmood, Maham, Monireh
Format: Article
Language:English
Subjects:
Acute Disease
Acute radiation dermatitis
Administration, Topical
Adult
Black cumin
Breast cancer
Breast Neoplasms - radiotherapy
Cancer therapies
Chemotherapy
Clinical trials
Dermatitis
Double-Blind Method
Double-blind studies
Edema
Female
Glycerol
Herbal medicine
Humans
Incidence
Medical prognosis
Middle Aged
Nigella sativa
Nigella sativa - chemistry
Nigella sativa L
Oncology
Pain
Patients
Phytotherapy - methods
Prevention
Quality of life
Radiation
Radiation therapy
Radiodermatitis - prevention & control
Radiotherapy
Radiotherapy - adverse effects
Skin
Surgery
Toxicity
Ulcers
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Summary:•Acute radiation dermatitis (ARD) is the most frequently reported adverse effect of the breast radiotherapy.•This study aimed to investigate Nigella sativa L. (N. sativa) 5% gel effectiveness in preventing ARD in breast cancer patients.•The preventive use of the N. sativa gel significantly decreased and delayed the incidence of ARD and related symptoms. The present study aimed to evaluate the effectiveness of Nigella sativa L. (N. sativa) extract on preventing the incidence of acute radiation dermatitis (ARD) in breast cancer patients. Sixty-two breast cancer patients undergoing radiotherapy (RT) were randomly assigned to receiveN. sativa 5% gel or placebo. Patients were instructed to apply the medications twice daily during RT period. The severity of ARD, the incidence of moist desquamation, worst experienced pain, and skin-related quality of life (SRQOL) scores were assessed weekly during RT. Patients who were treated with the N. sativa gel developed ARD significantly less frequently compared to those who used the placebo (p 
ISSN:0965-2299
1873-6963
DOI:10.1016/j.ctim.2019.102205