Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients

The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor ( LEPR ) and adiponectin ( ADIPOQ ) genes and these outcomes. Fo...

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Bibliographic Details
Published in:The pharmacogenomics journal 2020-06, Vol.20 (3), p.388-397
Main Authors: Gervasini, Guillermo, García-Pino, Guadalupe, Mota-Zamorano, Sonia, Luna, Enrique, García-Cerrada, Montserrat, Tormo, María Ángeles, Cubero, Juan José
Format: Article
Language:English
Subjects:
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692/308/2056
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Adiponectin
Adiponectin - genetics
Adult
Biomedical and Life Sciences
Biomedicine
Female
Follow-Up Studies
Gene Expression
Gene polymorphism
Genetic polymorphisms
Health aspects
Health risk assessment
Human Genetics
Humans
Immunosuppressive Agents - therapeutic use
Kidney Diseases - drug therapy
Kidney Diseases - genetics
Kidney Diseases - surgery
Kidney transplantation
Kidney Transplantation - trends
Kidneys
Leptin
Leptin - genetics
Male
Middle Aged
Oncology
Pharmacotherapy
Polymorphism, Single Nucleotide - genetics
Protein hormones
Psychopharmacology
Single-nucleotide polymorphism
Transplant Recipients
Transplantation
Transplants & implants
Treatment Outcome
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Summary:The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor ( LEPR ) and adiponectin ( ADIPOQ ) genes and these outcomes. Follow-up time ranged from 2 to 25 years (mean 10.29 ± 5.16 years). Two SNPs showed associations with long-term outcomes and their statistical significance greatly increased after 39 RTR with a history of cardiovascular events prior to transplantation were removed from the analysis. Adjusted odds ratios (OR) for LEPR rs1805094 and ADIPOQ rs1501299 and risk of graft loss were 0.35 (0.16–0.74) p  = 0.006 and 2.37 (1.28–4.37) p  = 0.006, respectively. The assessment of risk for global mortality revealed OR values of 0.20 (0.06–0.62), p  = 0.005, and 2.43 (1.08–5.44), p  = 0.031 for LEPR rs1805094 and ADIPOQ rs1501299, respectively. Our results show that polymorphism in genes involved in leptin and adiponectin function modify long-term outcomes in renal transplantation.
ISSN:1470-269X
1473-1150
DOI:10.1038/s41397-019-0128-7