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Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients
The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor ( LEPR ) and adiponectin ( ADIPOQ ) genes and these outcomes. Fo...
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| Published in: | The pharmacogenomics journal 2020-06, Vol.20 (3), p.388-397 |
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| container_end_page | 397 |
| container_issue | 3 |
| container_start_page | 388 |
| container_title | The pharmacogenomics journal |
| container_volume | 20 |
| creator | Gervasini, Guillermo García-Pino, Guadalupe Mota-Zamorano, Sonia Luna, Enrique García-Cerrada, Montserrat Tormo, María Ángeles Cubero, Juan José |
| description | The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor (
LEPR
) and adiponectin (
ADIPOQ
) genes and these outcomes. Follow-up time ranged from 2 to 25 years (mean 10.29 ± 5.16 years). Two SNPs showed associations with long-term outcomes and their statistical significance greatly increased after 39 RTR with a history of cardiovascular events prior to transplantation were removed from the analysis. Adjusted odds ratios (OR) for
LEPR
rs1805094 and
ADIPOQ
rs1501299 and risk of graft loss were 0.35 (0.16–0.74)
p
= 0.006 and 2.37 (1.28–4.37)
p
= 0.006, respectively. The assessment of risk for global mortality revealed OR values of 0.20 (0.06–0.62),
p
= 0.005, and 2.43 (1.08–5.44),
p
= 0.031 for
LEPR
rs1805094 and
ADIPOQ
rs1501299, respectively. Our results show that polymorphism in genes involved in leptin and adiponectin function modify long-term outcomes in renal transplantation. |
| doi_str_mv | 10.1038/s41397-019-0128-7 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2320640122</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A625089841</galeid><sourcerecordid>A625089841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c467t-20c85a7f956b459212b03a21941f319510992121ad488214c1aa1b42010c36393</originalsourceid><addsrcrecordid>eNp9Uk1r3DAQFaWhSbf9Ab0UQy-9ONVIsmUdl9AvCPTSQG5CK8sbBVtyJZmSf5_xbprQ0hYhRhq9N196hLwBeg6Udx-yAK5kTUHhZl0tn5EzEJLXAA19fjjTmrXq-pS8zPmWUmhBdi_IKUcjZSPOSN7mHK03xcdQxaGa43g3xTTf-DzlyodqdHNBY0Jfmd7PMTi73vcuuFz99OWmGmPY18WlqYpLsXFyB15ywYxVSSbkeTShoMP62btQ8ityMpgxu9cPdkOuPn38fvGlvvz2-evF9rK2opWlZtR2jZGDatqdaBQDtqPcMFACBg6qAapWJ5hedB0DYcEY2AlGgVrecsU35P0x7pzij8XloiefrRuxHBeXrBlntBU4OYbQd39Ab-OSsANECdlQzH8I-B8UlZwqybsn1N6MTvswRJyCXVPrbcsa2qkO_21Dzv-CwtW7yVsc8-DR_xsBjgSbYs7JDXpOfjLpTgPVqxz0UQ4a5aBXOWiJnLcPBS-7yfWPjF__jwB2BGR8CnuXnjr6d9R76hq9Bw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2407309738</pqid></control><display><type>article</type><title>Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients</title><source>Springer Link</source><creator>Gervasini, Guillermo ; García-Pino, Guadalupe ; Mota-Zamorano, Sonia ; Luna, Enrique ; García-Cerrada, Montserrat ; Tormo, María Ángeles ; Cubero, Juan José</creator><creatorcontrib>Gervasini, Guillermo ; García-Pino, Guadalupe ; Mota-Zamorano, Sonia ; Luna, Enrique ; García-Cerrada, Montserrat ; Tormo, María Ángeles ; Cubero, Juan José</creatorcontrib><description>The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor (
LEPR
) and adiponectin (
ADIPOQ
) genes and these outcomes. Follow-up time ranged from 2 to 25 years (mean 10.29 ± 5.16 years). Two SNPs showed associations with long-term outcomes and their statistical significance greatly increased after 39 RTR with a history of cardiovascular events prior to transplantation were removed from the analysis. Adjusted odds ratios (OR) for
LEPR
rs1805094 and
ADIPOQ
rs1501299 and risk of graft loss were 0.35 (0.16–0.74)
p
= 0.006 and 2.37 (1.28–4.37)
p
= 0.006, respectively. The assessment of risk for global mortality revealed OR values of 0.20 (0.06–0.62),
p
= 0.005, and 2.43 (1.08–5.44),
p
= 0.031 for
LEPR
rs1805094 and
ADIPOQ
rs1501299, respectively. Our results show that polymorphism in genes involved in leptin and adiponectin function modify long-term outcomes in renal transplantation.</description><identifier>ISSN: 1470-269X</identifier><identifier>EISSN: 1473-1150</identifier><identifier>DOI: 10.1038/s41397-019-0128-7</identifier><identifier>PMID: 31787754</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/77 ; 692/308/2056 ; 692/308/53 ; Adiponectin ; Adiponectin - genetics ; Adult ; Biomedical and Life Sciences ; Biomedicine ; Female ; Follow-Up Studies ; Gene Expression ; Gene polymorphism ; Genetic polymorphisms ; Health aspects ; Health risk assessment ; Human Genetics ; Humans ; Immunosuppressive Agents - therapeutic use ; Kidney Diseases - drug therapy ; Kidney Diseases - genetics ; Kidney Diseases - surgery ; Kidney transplantation ; Kidney Transplantation - trends ; Kidneys ; Leptin ; Leptin - genetics ; Male ; Middle Aged ; Oncology ; Pharmacotherapy ; Polymorphism, Single Nucleotide - genetics ; Protein hormones ; Psychopharmacology ; Single-nucleotide polymorphism ; Transplant Recipients ; Transplantation ; Transplants & implants ; Treatment Outcome</subject><ispartof>The pharmacogenomics journal, 2020-06, Vol.20 (3), p.388-397</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2019</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-20c85a7f956b459212b03a21941f319510992121ad488214c1aa1b42010c36393</citedby><cites>FETCH-LOGICAL-c467t-20c85a7f956b459212b03a21941f319510992121ad488214c1aa1b42010c36393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31787754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gervasini, Guillermo</creatorcontrib><creatorcontrib>García-Pino, Guadalupe</creatorcontrib><creatorcontrib>Mota-Zamorano, Sonia</creatorcontrib><creatorcontrib>Luna, Enrique</creatorcontrib><creatorcontrib>García-Cerrada, Montserrat</creatorcontrib><creatorcontrib>Tormo, María Ángeles</creatorcontrib><creatorcontrib>Cubero, Juan José</creatorcontrib><title>Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients</title><title>The pharmacogenomics journal</title><addtitle>Pharmacogenomics J</addtitle><addtitle>Pharmacogenomics J</addtitle><description>The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor (
LEPR
) and adiponectin (
ADIPOQ
) genes and these outcomes. Follow-up time ranged from 2 to 25 years (mean 10.29 ± 5.16 years). Two SNPs showed associations with long-term outcomes and their statistical significance greatly increased after 39 RTR with a history of cardiovascular events prior to transplantation were removed from the analysis. Adjusted odds ratios (OR) for
LEPR
rs1805094 and
ADIPOQ
rs1501299 and risk of graft loss were 0.35 (0.16–0.74)
p
= 0.006 and 2.37 (1.28–4.37)
p
= 0.006, respectively. The assessment of risk for global mortality revealed OR values of 0.20 (0.06–0.62),
p
= 0.005, and 2.43 (1.08–5.44),
p
= 0.031 for
LEPR
rs1805094 and
ADIPOQ
rs1501299, respectively. Our results show that polymorphism in genes involved in leptin and adiponectin function modify long-term outcomes in renal transplantation.</description><subject>45/77</subject><subject>692/308/2056</subject><subject>692/308/53</subject><subject>Adiponectin</subject><subject>Adiponectin - genetics</subject><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene Expression</subject><subject>Gene polymorphism</subject><subject>Genetic polymorphisms</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Kidney Diseases - drug therapy</subject><subject>Kidney Diseases - genetics</subject><subject>Kidney Diseases - surgery</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - trends</subject><subject>Kidneys</subject><subject>Leptin</subject><subject>Leptin - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Pharmacotherapy</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Protein hormones</subject><subject>Psychopharmacology</subject><subject>Single-nucleotide polymorphism</subject><subject>Transplant Recipients</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><issn>1470-269X</issn><issn>1473-1150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9Uk1r3DAQFaWhSbf9Ab0UQy-9ONVIsmUdl9AvCPTSQG5CK8sbBVtyJZmSf5_xbprQ0hYhRhq9N196hLwBeg6Udx-yAK5kTUHhZl0tn5EzEJLXAA19fjjTmrXq-pS8zPmWUmhBdi_IKUcjZSPOSN7mHK03xcdQxaGa43g3xTTf-DzlyodqdHNBY0Jfmd7PMTi73vcuuFz99OWmGmPY18WlqYpLsXFyB15ywYxVSSbkeTShoMP62btQ8ityMpgxu9cPdkOuPn38fvGlvvz2-evF9rK2opWlZtR2jZGDatqdaBQDtqPcMFACBg6qAapWJ5hedB0DYcEY2AlGgVrecsU35P0x7pzij8XloiefrRuxHBeXrBlntBU4OYbQd39Ab-OSsANECdlQzH8I-B8UlZwqybsn1N6MTvswRJyCXVPrbcsa2qkO_21Dzv-CwtW7yVsc8-DR_xsBjgSbYs7JDXpOfjLpTgPVqxz0UQ4a5aBXOWiJnLcPBS-7yfWPjF__jwB2BGR8CnuXnjr6d9R76hq9Bw</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Gervasini, Guillermo</creator><creator>García-Pino, Guadalupe</creator><creator>Mota-Zamorano, Sonia</creator><creator>Luna, Enrique</creator><creator>García-Cerrada, Montserrat</creator><creator>Tormo, María Ángeles</creator><creator>Cubero, Juan José</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20200601</creationdate><title>Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients</title><author>Gervasini, Guillermo ; García-Pino, Guadalupe ; Mota-Zamorano, Sonia ; Luna, Enrique ; García-Cerrada, Montserrat ; Tormo, María Ángeles ; Cubero, Juan José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-20c85a7f956b459212b03a21941f319510992121ad488214c1aa1b42010c36393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>45/77</topic><topic>692/308/2056</topic><topic>692/308/53</topic><topic>Adiponectin</topic><topic>Adiponectin - genetics</topic><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene Expression</topic><topic>Gene polymorphism</topic><topic>Genetic polymorphisms</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Kidney Diseases - drug therapy</topic><topic>Kidney Diseases - genetics</topic><topic>Kidney Diseases - surgery</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - trends</topic><topic>Kidneys</topic><topic>Leptin</topic><topic>Leptin - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Pharmacotherapy</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Protein hormones</topic><topic>Psychopharmacology</topic><topic>Single-nucleotide polymorphism</topic><topic>Transplant Recipients</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gervasini, Guillermo</creatorcontrib><creatorcontrib>García-Pino, Guadalupe</creatorcontrib><creatorcontrib>Mota-Zamorano, Sonia</creatorcontrib><creatorcontrib>Luna, Enrique</creatorcontrib><creatorcontrib>García-Cerrada, Montserrat</creatorcontrib><creatorcontrib>Tormo, María Ángeles</creatorcontrib><creatorcontrib>Cubero, Juan José</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The pharmacogenomics journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gervasini, Guillermo</au><au>García-Pino, Guadalupe</au><au>Mota-Zamorano, Sonia</au><au>Luna, Enrique</au><au>García-Cerrada, Montserrat</au><au>Tormo, María Ángeles</au><au>Cubero, Juan José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients</atitle><jtitle>The pharmacogenomics journal</jtitle><stitle>Pharmacogenomics J</stitle><addtitle>Pharmacogenomics J</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>20</volume><issue>3</issue><spage>388</spage><epage>397</epage><pages>388-397</pages><issn>1470-269X</issn><eissn>1473-1150</eissn><abstract>The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor (
LEPR
) and adiponectin (
ADIPOQ
) genes and these outcomes. Follow-up time ranged from 2 to 25 years (mean 10.29 ± 5.16 years). Two SNPs showed associations with long-term outcomes and their statistical significance greatly increased after 39 RTR with a history of cardiovascular events prior to transplantation were removed from the analysis. Adjusted odds ratios (OR) for
LEPR
rs1805094 and
ADIPOQ
rs1501299 and risk of graft loss were 0.35 (0.16–0.74)
p
= 0.006 and 2.37 (1.28–4.37)
p
= 0.006, respectively. The assessment of risk for global mortality revealed OR values of 0.20 (0.06–0.62),
p
= 0.005, and 2.43 (1.08–5.44),
p
= 0.031 for
LEPR
rs1805094 and
ADIPOQ
rs1501299, respectively. Our results show that polymorphism in genes involved in leptin and adiponectin function modify long-term outcomes in renal transplantation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31787754</pmid><doi>10.1038/s41397-019-0128-7</doi><tpages>10</tpages></addata></record> |
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| ispartof | The pharmacogenomics journal, 2020-06, Vol.20 (3), p.388-397 |
| issn | 1470-269X 1473-1150 |
| language | eng |
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| source | Springer Link |
| subjects | 45/77 692/308/2056 692/308/53 Adiponectin Adiponectin - genetics Adult Biomedical and Life Sciences Biomedicine Female Follow-Up Studies Gene Expression Gene polymorphism Genetic polymorphisms Health aspects Health risk assessment Human Genetics Humans Immunosuppressive Agents - therapeutic use Kidney Diseases - drug therapy Kidney Diseases - genetics Kidney Diseases - surgery Kidney transplantation Kidney Transplantation - trends Kidneys Leptin Leptin - genetics Male Middle Aged Oncology Pharmacotherapy Polymorphism, Single Nucleotide - genetics Protein hormones Psychopharmacology Single-nucleotide polymorphism Transplant Recipients Transplantation Transplants & implants Treatment Outcome |
| title | Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients |
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