Diagnostic and prognostic impact of circulating microRNA-208b and microRNA-499 in patients with acute coronary syndrome

This study aimed to investigate the correlation between the expression of circulating miR-208b and miR-499 and acute coronary syndrome (ACS) patients. A total of 160 consecutive patients with ACS and 48 healthy control subjects were enrolled for primary analysis. The ACS patients (n = 160) were foll...

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Bibliographic Details
Published in:Biomarkers in medicine 2020-02, Vol.14 (2), p.87-95
Main Authors: Wang, Wei, Li, Tai, Gao, Lei, Li, Yang, Sun, Ying, Yao, Heng-Chen
Format: Article
Language:English
Subjects:
acute coronary syndrome
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - diagnosis
Acute Coronary Syndrome - genetics
Acute coronary syndromes
Aged
Angina pectoris
biomarker
Biomarkers
Biomarkers - blood
Biomarkers - metabolism
Cardiovascular disease
Cholesterol
Circulating MicroRNA - genetics
Coronary vessels
Creatinine
Disease-Free Survival
Female
Gene expression
Gene Expression Regulation
Heart
Heart attacks
Heart failure
Hemoglobin
Humans
major adverse cardiac events
Male
MicroRNAs
MicroRNAs - genetics
Middle Aged
miR-208b
miR-499
miRNA
Normal distribution
Prognosis
ROC Curve
Statistical analysis
Values
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Summary:This study aimed to investigate the correlation between the expression of circulating miR-208b and miR-499 and acute coronary syndrome (ACS) patients. A total of 160 consecutive patients with ACS and 48 healthy control subjects were enrolled for primary analysis. The ACS patients (n = 160) were followed up for 6 months for further analysis regarding major adverse cardiac events. Area under the curve values of miR-208b and miR-499 for predicting ACS were 0.910 and 0.851 (p < 0.001, respectively). Cox proportional hazards regression analysis revealed that miR-208b but not miR-499 was an independent predictor of major adverse cardiac events. Circulating miR-208b and miR-499 could be considered as diagnostic or prognostic biomarkers for patients with ACS.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2019-0257