Doppler gradients, valve area and ventricular function in pregnant women with aortic or pulmonary valve disease: Left versus right

Little is known about the course of echocardiographic parameters used for the evaluation of valvular heart disease (VHD) during pregnancy, hampering interpretation of possible changes (physiological vs. pathophysiological). Therefore we studied the course of these parameters and ventricular function...

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Bibliographic Details
Published in:International journal of cardiology 2020-05, Vol.306, p.152-157
Main Authors: Siegmund, Anne S., Pieper, Petronella G., Mulder, Barbara J.M., Sieswerda, Gertjan Tj, van Dijk, Arie P.J., Roos-Hesselink, Jolien W., Jongbloed, Monique R.M., Konings, Thelma C., Bouma, Berto J., Groen, Henk, Sollie-Szarynska, Krystyna M., Kampman, Marlies A.M., Bilardo, Caterina M., van Veldhuisen, Dirk J., Aalberts, Jan J.J.
Format: Article
Language:English
Subjects:
Aortic Valve
Aortic Valve Stenosis
Echocardiography
Female
Heart Valve Diseases - diagnostic imaging
Heart Valve Diseases - epidemiology
Humans
Pregnancy
Pregnant Women
Prospective Studies
Pulmonary Valve - diagnostic imaging
Stroke Volume
Valve area
Valvular Doppler gradients
Valvular heart disease
Ventricular function
Ventricular Function, Left
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Summary:Little is known about the course of echocardiographic parameters used for the evaluation of valvular heart disease (VHD) during pregnancy, hampering interpretation of possible changes (physiological vs. pathophysiological). Therefore we studied the course of these parameters and ventricular function in pregnant women with aortic and pulmonary VHD. The cohort comprised 66 pregnant women enrolled in the prospective ZAHARA studies or evaluated by an identical protocol who had pulmonary VHD or aortic VHD (stenosis/prosthetic valve). The control group comprised 46 healthy pregnant women. Echocardiography was performed preconception, during pregnancy and 1 year postpartum. Peak gradient, mean gradient, aortic valve area (AVA)/effective orifice area (EOA), left ventricular ejection fraction (LVEF) and right ventricular function (RVF; TAPSE) were assessed. Peak and mean gradients increased during pregnancy compared to preconception in women with aortic VHD and controls (p 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2019.11.118