Analysis of the chemical components of Qixianqingming granules and their metabolites in rats by UPLC‐ESI‐Q‐TOF‐MS

Qixianqingming granules (QXQM) comprise a traditional Chinese medicine (TCM) formula that was developed based on the combination of TCM theory and clinical practice. This formula has been proven to effectively treat asthma. In this study, an analytical procedure using ultraperformance liquid chromat...

Full description

Saved in:
Bibliographic Details
Published in:Journal of mass spectrometry. 2020-01, Vol.55 (1), p.e4484-n/a
Main Authors: Zhang, Bei, Li, Mo Ying, Luo, Xu Ming, Wang, Xiong Biao, Wu, Tong
Format: Article
Language:English
Subjects:
Alkaloids
Alkaloids - analysis
Alkaloids - metabolism
Analytical methods
Animals
Anthraquinones
Anthraquinones - analysis
Anthraquinones - metabolism
Asthma
chemical components
Chinese medicine
Chromatography, High Pressure Liquid
Components
Drugs, Chinese Herbal - metabolism
Drugs, Chinese Herbal - pharmacokinetics
Flavonoids
Flavonoids - analysis
Flavonoids - metabolism
Glycosides
Glycosides - analysis
Glycosides - metabolism
Granular materials
Herbal medicine
Ionization
Ions
Liquid chromatography
Male
Mass spectrometry
Mass spectroscopy
Metabolites
Organic acids
Organic chemistry
Prototypes
Qixianqingming granules (QXQM)
Quadrupoles
Rats
Rats, Sprague-Dawley
Serum
Spectrometry, Mass, Electrospray Ionization - methods
Stilbenes - analysis
Stilbenes - metabolism
Tandem Mass Spectrometry - methods
TCM
Terpenes
Terpenes - analysis
Terpenes - metabolism
Traditional Chinese medicine
UPLC‐ESI‐Q‐TOF‐MS
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Qixianqingming granules (QXQM) comprise a traditional Chinese medicine (TCM) formula that was developed based on the combination of TCM theory and clinical practice. This formula has been proven to effectively treat asthma. In this study, an analytical procedure using ultraperformance liquid chromatography, coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry, was established for the rapid separation and sensitive identification of the chemical components in QXQM and its metabolites in serum of rats. Seventy‐two compounds were systematically identified in QXQM, including flavonoids, terpenoids, anthraquinones, phenylethanoid glycosides, stilbenes, alkaloids, and organic acids. Thirteen prototype compounds and 29 metabolites were detected in the serum of rats. The results provided fundamental information for further studying the mechanisms and clinical application of QXQM.
ISSN:1076-5174
1096-9888
DOI:10.1002/jms.4484