Cortical hypoperfusion in patients with idiopathic rapid eye movement sleep behavior disorder detected with arterial spin-labeled perfusion MRI

• Published in: Neurological sciences 2020-04, Vol.41 (4), p.809-815
• Main Authors: Chen, Yonglu, Fan, Changhe, Yang, Wanqun, Nie, Kun, Wu, Xiaoling, Yang, Yuelong, Yang, Yunjun, Wang, Lijuan, Zhang, Yuhu, Huang, Biao
• Format: Article
• Language: English
• Subjects: Aged; Behavior disorders; Blood flow; Cerebral blood flow; Cerebral cortex; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiopathology; Cerebrovascular Circulation - physiology; Eye movements; Female; Frontal gyrus; Gender; Humans; Magnetic Resonance Angiography; Magnetic resonance imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Neuroimaging; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Original Article; Perfusion; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiopathology; Psychiatry; REM sleep; REM Sleep Behavior Disorder - diagnostic imaging; REM Sleep Behavior Disorder - physiopathology; Risk factors; Sleep disorders; Spin Labels; Synucleinopathies - diagnostic imaging; Synucleinopathies - physiopathology
• ISSN: 1590-1874; 1590-3478
• DOI: 10.1007/s10072-019-04118-5

Background Idiopathic rapid eye movement sleep behavior disorder (iRBD) is an important risk factor for α-synucleinopathy. Objective We investigated alterations in the cerebral blood flow (CBF) based on arterial spin-labeled (ASL) imaging in patients with iRBD to determine brain perfusion changes associated with the disorder. Methods Fifteen patients with iRBD and twenty age–gender-matched healthy controls were enrolled. Cortical perfusions were compared between the two groups after the ASL data was co-registered to the high-resolution T1-weighted images. Results No significant differences were detected between the groups in regard to age, gender, education, or UPDRS-III score. The iRBD group showed a lower MMSE score than the healthy controls (27.07 ± 2.25 vs. 28.55 ± 1.23, p