Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat

Diets rich in saturated fats and cholesterol contribute to the incidence of hyperlipidaemia. An altered lipid profile is a major factor responsible for the development of CVD. Male Wistar rats were fed with a high‐fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic...

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Bibliographic Details
Published in:Clinical and experimental pharmacology & physiology 2020-04, Vol.47 (4), p.571-582
Main Authors: Kumar, Raushan, Akhtar, Farhan, Rizvi, Syed Ibrahim
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
Animal models
Antioxidants
Biomarkers
Body weight
Carbonyl compounds
Carbonyls
Cholesterol
Cholic acid
Coconut oil
CVD
Cytokines
Diet
Dietary supplements
Fasting
Fats
Glucose
Glutamic oxaloacetic transaminase
Glutathione
Hesperidin
High fat diet
Homeostasis
hyperlipidaemia
Hyperlipidemia
Inflammation
Insulin
Interleukins
Lipids
Malondialdehyde
Mathematical models
Oils & fats
Oxidation
Oxidative stress
Parameters
Paraoxonase
Proteins
Reactive oxygen species
Rodents
ROS
Transaminase
Triglycerides
Tumor necrosis factor-TNF
Tumors
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Summary:Diets rich in saturated fats and cholesterol contribute to the incidence of hyperlipidaemia. An altered lipid profile is a major factor responsible for the development of CVD. Male Wistar rats were fed with a high‐fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) to induce an experimental hyperlipidaemic model. High‐fat diet fed rats were also supplemented with hesperidin (100 mg/kg body weight). The present study reports reactive oxygen species (ROS) production, oxidative stress parameters: malondialdehyde (MDA), protein carbonyl (PCO), oxidation of plasma protein (AOPP), and advance glycation end products (AGEs); antioxidant defence parameters: ferric reducing ability of plasma (FRAP), reduced glutathione (GSH), Paraoxonase‐1 (PON‐1), plasma membrane redox system (PMRS); general biochemical parameters: triglyceride, cholesterol, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvic transaminase (SGPT), fasting insulin, fasting glucose, homeostatic model assessment–insulin resistance (Homa‐IR) index, and inflammatory biomarkers: interleukin (IL)‐6 and tumour necrosis factor (TNF)‐α. Experimental hyperlipidaemia was found to be associated with significantly higher body weight (27.58%), cholesterol (140%), triglyceride (190%), and fasting glucose level (37%). Reactive oxygen species production (67%), MDA (28.9%), AOPP (31.42%), PCO (58.53%), and PMRS (156%), inflammatory markers, cytokines IL‐6 and TNF‐α, were elevated and GSH (50%), PON 1 (37.07%), and FRAP (26.58%) activity were significantly (P 
ISSN:0305-1870
1440-1681
DOI:10.1111/1440-1681.13221